COMPARING PERFORMANCE-BASED MEASURES AND SELF-REPORTED QUESTIONNAIRES FOR ASSESSMENT OF EXECUTIVE FUNCTION FOR YOUTH WITH CHILDHOOD-ONSET SYSTEMIC LUPUS ERYTHEMATOSUS
Notice bibliographique
Résumé
PV162 / #428 Poster Topic: AS18 - Pediatric SLE Background/Purpose Executive dysfunction is common in childhood-onset systemic lupus erythematosus (cSLE). Comprehensive neuropsychological assessments use both performance-based measures and standardized questionnaires, capturing different cognitive constructs. However, comprehensive assessments are time-consuming, resource-intensive, and often inaccessible. Standardized questionnaires measuring self-rated daily executive function (EF), are brief and easy to administer, with potential clinical utility to identify patients needing comprehensive assessment. The study aimed to examine associations between performance-based measures and self-rating of daily EF in youth with cSLE. Methods This cross-sectional study analyzed prospectively collected data from cSLE patients (meeting ACR 1997 or SLICC classification criteria) aged 11-17 years recruited from an outpatient Lupus Clinic from January 2020–December 2023, and age and sex-matched healthy controls. Participants completed the Behaviour Rating Inventory of Executive Function 2nd Edition Self-Report Form (BRIEF-2-SR) assessing daily EF measured by the General Executive Composite (GEC), Behavior Regulation Index (BRI), Cognitive Regulation Index (CRI), and Emotion Regulation Index (ERI). The Delis-Kaplan Executive Function System (D-KEFS) Color-Word Interference Test (CWIT), a performance-based measure, assessed information processing speed (Color Naming, Word Reading), cognitive inhibition and flexibility (Inhibition, Inhibition/Switching). Correlations were calculated between the BRIEF-2-SR summary scores (GEC, BRI, CRI, and ERI) and scaled scores for performance in the 4 tasks of the D-KEFS CWIT. Mann-Whitney U tests were used to examine group differences in scores. Results There was a total of 58 cSLE participants (84% female; mean age=15.3y ± SD 1.7) and 47 controls (83% female; mean age=14.9y ± SD 1.9) (Table 1). For cSLE participants, worse performance-based scores for cognitive inhibition and flexibility showed statistically significantly correlations with worse self-rated daily EF scores for the GEC, BRI, and ERI (Figure 1). For controls, worse scores for cognitive inhibition and flexibility correlated with worse self-rated daily EF scores for GEC and CRI (Figure 1). Performance-based processing speed scores were not significantly associated with the BRIEF-2 scores in either group. No significant differences were found between cSLE and controls across BRIEF-2-SR indices. On the D-KEFS, cSLE participants displayed significantly poorer performance on Color Naming (U = 1027, p = 0.022), Inhibition (U = 1027, p = 0.021), and Inhibition/Switching (U = 1049, p = 0.030) compared to controls. Table 1. Demographics and Disease Characteristics Figure 1: Spearman Rho correlation matrices depicting the associations between BRIEF-2-SR (higher scores indicating worse executive function) and D-KEFS (lower scores indicating worse executive function) measures for childhood-onset systemic lupus erythematosus (cSLE) participants and controls. * Denotes significance (p < 0.05) Conclusions Youth with cSLE in this cohort had worse performance-based EF measures compared to controls. Performance-based scores for cognitive inhibition and flexibility correlated with self-rated daily EF scores in both groups, but more consistently across indices in the cSLE group. Further study is needed to determine the utility of questionnaires for self-rated daily EF as efficient screening tools to identify cSLE patients needing comprehensive neuropsychological assessment.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,003 | 0,007 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,001 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».