166 Effects of excess zinc in drinking water of weaned piglets in a natural viral infection model
Notice bibliographique
Résumé
Abstract Porcine reproductive and respiratory syndrome (PRRS) causes significant losses in the Canadian swine industry. Zinc oxide is commonly used to support gut health and the immune system in animals post-weaning, but its digestibility is limited, and its widespread use causes environmental issues. In response to new regulations limiting the use of zinc oxide, finding alternatives has become crucial. This study aimed to test the effect of a zinc-lysine complex offered in water using a natural disease challenge model (NDCM). The study was conducted on five groups of 60 weaned piglets that were monitored to evaluate the effect of zinc-lysine in water. Each group was divided into four pens of 15 piglets, with one control group and two groups receiving 500 ppm (ZnH) and 1000 ppm (ZnVH) of zinc-lysine in water. Treatments lasted 29 days. Feed and water intake were measured. All piglets received conventional feed without additional Zn as a growth factor. Manual weighing was conducted on days 0, 15, 29, and at the end of the nursery phase, with weekly health scores assigned until the end of nursery. Blood samples were also taken on days 15 and 29 from 8 piglets per pen. Statistical analyses were performed using Minitab’s mixed procedure with treatment and sex as fixed effects and group as a random effect. For the 0-29 day period, average daily feed intake was not influenced by treatments. Average daily gain was lower for ZnVH (192 g/day; P=0.005) compared to the control (222 g/day) and ZnH (240 g/day), which did not differ statistically. Feed conversion was higher for ZnVH (1.86) compared to ZnH (1.44; P=0.018), with the control being intermediate (1.67). On day 29, the weight of animals in the ZnH group (13.6 kg) was higher than ZnVH (11.6 kg; P=0.007), with the control group being intermediate (12.9 kg). On days 7 (P=0.045), 15 (P=0.018), and 29 (P=0.044), health scores deteriorated for ZnVH compared to ZnH, which had the best score and did not differ from the control. Finally, on day 29, plasma zinc levels for the ZnVH treatment (2.10 ppm) were higher than for the control (0.613 ppm) and ZnH (1.36 ppm; P< 0.05). The results of the study show that adding zinc-lysine to water can benefit weaned piglets infected with the PRRS virus. However, an excess of zinc appears to lead to toxic effects, compromising piglet health and growth performance. This study shows that zinc-lysine may be an effective alternative to zinc oxide, but the optimal dose of Zn still needs to be fine-tune.
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».