The relationship between grip strength, 6 minute walking distance and working memory in older adults with mild cognitive impairment: an fNIRS study
Notice bibliographique
Résumé
OBJECTIVE: Functional near-infrared spectroscopy (fNIRS) was employed to explore the potential relationship between grip strength, 6-minute walking distance (6MWD), and working memory in older adults with mild cognitive impairment (MCI). METHODS: Participants aged 60 years and above were recruited and assessed using the Montreal Cognitive Assessment (MoCA). Grip strength and 6MWD were measured, and fNIRS was utilized to monitor blood flow changes in the prefrontal lobe during an N-back task. RESULTS: A total of 72 participants were recruited, aged between 70 and 95 years, with MoCA scores ranging from 10 to 25 points. The MoCA score was most strongly correlated with 1-back performance (r = -0.423, p < 0.001), followed by 0-back performance, and showed no significant correlation with 2-back performance. The activation levels of several channels in the left dorsolateral prefrontal cortex (ch17, ch19, ch23), right dorsolateral prefrontal cortex (ch8), and right ventrolateral prefrontal cortex (ch2) were significantly higher in the high-performance group for 1-back compared to the low-performance group (p = 0.016, p = 0.008, p = 0.013; p = 0.018; p = 0.043). Grip strength and 6MWD were both significantly correlated with working memory performance under all three levels of cognitive load, with the strongest correlation observed for 1-back performance (grip strength: r = -0.377, p = 0.001; 6MWD: r = -0.382, p = 0.001). Grip strength was positively correlated with the activation levels of ch17 and ch19 (r = 0.234, p = 0.048; r = 0.249, p = 0.035), and significant inter-group differences were found for the activation level of ch19 (p = 0.032). Similarly, 6MWD was positively correlated with the activation levels of ch17 and ch2 (r = 0.312, p = 0.008; r = 0.256, p = 0.030), with significant inter-group differences observed in the activation levels of ch17, ch19, and ch2 (p = 0.007; p = 0.022; p = 0.029). CONCLUSION: Cognitive decline in older adults with MCI was associated with a decline in working memory, with 1-back performance being the most sensitive measure. The brain mechanisms underlying this sensitivity involved higher activation levels in the left dorsolateral prefrontal cortex, right dorsolateral prefrontal cortex, and right ventrolateral prefrontal cortex. Older adults with stronger muscle strength and better cardiopulmonary function maintained better working memory, with higher activation levels in the left dorsolateral prefrontal cortex. However, the specific activation channels were not entirely consistent across individuals. CLINICAL TRIAL NUMBER: Not applicable.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».