Baseline Serum Osteopontin (OPN) Level Is Associated with Early Coronary Artery Calcification and its Progression in Patients with Systemic Lupus Erythematosus
Notice bibliographique
Résumé
Objectives To determine the incidence and progression of coronary artery calcification (CAC) To determine whether OPN serum levels are associated with progression of CAC in SLE patients.[1,2] Methods Inception Cohort. Since enrollment into the cohort, all patients had a standardized medical history, physical examination, and laboratory tests, including lipid profile, apoB, homocysteine, high-sensitivity C-reactive protein (hs-CRP), serum complement (C3 and C4), and autoantibodies. Every 3-6 months, patients were seen at the lupus clinic for medical care, and assessments of disease activity using the SLE disease activity scores, and medications usage. Every year, information was updated, including lupus characteristics, damage accrual, any comorbidities, traditional cardiovascular risk factors, and a blood sample has been drawn. In 2008, 104 lupus patients from the cohort (93% females) were screened for coronary artery calcifications using Multidetector Computed Tomography, after first 5 years of follow-up. In 2018 a follow-up screening for CAC was carried up. Progression of CAC was considered positive if i) patients without CAC in 2008 were found with CAC+ in the second screening or ii) patients with CAC positive in 2008 were found with any increase of their Calcium Score. OPN plasma levels were measured by ELISA. Correlates for calcifications were analyzed. Cumulative incidence of CAC was calculated and risk factors for CAC progression were identified by multivariate analysis. Results At enrollment, lupus patients were 27.2+9.1 years of age and disease duration 5.4+3.8 months. On 2008 during the first CT screening, CAC were detected in 7.2% of patients, since age 23 years, and from 3 years of disease duration. At follow-up screening, progression of CAC was identified in 16.3% (IC95% 10.4-24.6). Cumulative incidence of CAC was observed in 9%. Mean value of OPN level at baseline was 102.7 ng/mL (95% CI = 89.3-116.1 ng/mL). Earlier Risk factors associated with CAC were disease activity (p=0.03) and disease duration (p=0.03) while risk factors for progression of CAC were postmenopausal status (p=0.01), apoB levels (p=0.01) and OPN levels (p=0.009). There was a positive correlation for progression of CAC and adjusted mean SLEDAI at first 5 years of follow-up and baseline OPN levels (p=0.006). Conclusion Our findings suggest that in patients with SLE, early CAC is associated with disease severity while in the progression of CAC, traditional risk factors for atherosclerosis and OPN level were adding. [1.] Bathon JM. Arthritis Res Ther 2023;25(1):213. [2.] Kadoglou NPE. Biomedicines 2023;11(12):3178.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,002 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».