Effect of probiotic therapy on the clinical manifestations of neuropsychiatric disorders in patients with dysbiotic changes
Notice bibliographique
Résumé
Aim: to assess the duration and changes of psychoneurological and gastrointestinal disorders in patients with psychoneurological conditions following the addition of a probiotic product containing lactobacilli LGG® and bifidobacteria BB-12® to comprehensive therapy. Materials and Methods: a retrospective study included 100 patients (59 female), aged over 18 years (range: 18–95 years; mean age: 49±8.6 years), presenting with psychoneurological symptoms: somatoform disorder (n=37), bipolar disorder (n=9), schizophrenia or schizoaffective disorder (n=12), parkinsonism (n=35, including Parkinson’s disease, n=19), Alzheimer’s disease (n=1), unspecified dementia (n=2), and autism (n=4). Gastrointestinal (GI) complaints were reported in 84 patients, most frequently abdominal discomfort and episodic abdominal pain (n=78), accompanied by constipation (n=47), diarrhea (n=18), or alternating constipation and diarrhea (n=9). Less commonly observed were poor appetite (n=48), recommended food aversion (n=21), nausea (n=18), and episodes of vomiting (n=8). Initial laboratory microbiological assessment confirmed intestinal dysbiosis in 100% of patients, and oropharyngeal dysbiosis was detected in 65%. Using a case-control design, patients were divided into two groups of 50 each: in the main group, patients received a probiotic preparation in addition to standard therapy for 21 days, while in the comparison group, correction was performed by other means or dietary modification alone. Clinical symptoms were evaluated on days 5±1, 10±1, 20±2, 30±3, 60±3, 90±3, and 180±10 from therapy initiation. Microbiological diagnostics for dysbiosis were performed before treatment and on day 30±3. The changes of psychoneurological symptoms were assessed, including anxiety and sleep disturbances (using the Hamilton scale), productive symptoms—such as delusions and hallucinations, if present (using the SAPS or Young scales), self-care ability (Barthel Index), and learning ability (Montreal Cognitive Assessment). Results and Discussion: probiotic therapy was associated with more rapid resolution of abdominal discomfort and pain, as well as normalization of bowel function. Upon completion of the probiotic course and in subsequent follow-ups, an improvement in mental status was observed. At the 30±3 day time point, improvement in gut microbiome composition was noted in 100% of patients in the main group, compared to only 23 (46%) in the comparison group (p<0.05). The incidence of acute respiratory viral infections (ARVI) over 6 months was lower in the main group than in the comparison group — 1.3±0.74 vs. 1.9±1.17 (p<0.05). Conclusion: probiotic therapy with product containing lactobacilli LGG® and bifidobacteria BB-12® in adult patients with psychoneurological disorders and concomitant GI dysbiosis characterized by abdominal discomfort or pain, bowel dysfunction, and appetite disorders, leads to faster alleviation or reduction in the severity of complaints, improvement in mental condition, reduced ARVI incidence, and improved laboratory indicators of microbiome composition compared to alternative treatment regimens. Keywords: Bifidobacteria spp., Lactobacillus spp., Bifidobacteria BB-12, dysbiosis, intestine, Lactobacilli LGG, microbiome, probiotics, mental disorders. For citation: Ruzhentsova T.A., Garbuzov A.A., Bayrakova A.L. Effect of probiotic therapy on the clinical manifestations of neuropsychiatric disorders in patients with dysbiotic changes. RMJ. 2025;5:22–28. DOI: 10.32364/2225-2282-2025-5-5
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Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».