Impact of Dolutegravir-based regimens on patient satisfaction and quality of life among people living with HIV: A systematic review and meta-analysis protocol
Notice bibliographique
Résumé
Introduction: The use of antiretroviral therapy (ART) in HIV management has closed the gap in life expectancies between Persons Living with HIV (PLHIV) and the general populace, leading to longevity among PLHIVs. However, increased life expectancies or longevity do not translate to better treatment satisfaction and Quality of Life (QoL). Available literature indicates a divergence in findings with regards the effect of ART on patient satisfaction levels and QoL. With dolutegravir (DTG)-based regimens currently the mainstay of HIV management, there is the need to ascertain effects of DTG on patient satisfaction and QoL among PLHIV. Thus, the aim of this study is to review the existing literature and pool the patient satisfaction levels and QoL among PLHIV exposed to DTG. Methods: This is a systematic review and meta-analysis. Study outcomes will be the mean values of the QoL, as well as the proportions, odds ratios and risk ratios of patient satisfaction with DTG. Searches will be conducted on PubMed and Scopus databases, with search period limited to the last 10 years. Studies that reported on the effect of DTG on our outcomes of interest will be included. For studies where the study population was exposed to other integrase strand transfer inhibitors or other ART classes, we will collect data separately for the outcomes of those exposed to DTG and those of the comparator. Also, included studies will be peer-reviewed articles that utilized standardized assessment tools to evaluate QoL among PLHIV exposed to DTG. Conversely, this review will exclude case studies, commentaries, editorials, and all forms of reviews. The study will employ the Preferred Reporting Items for Systematic Review and Meta-analysis checklist. Data extraction and screening will be conducted by 4 independent reviewers. Quality assessment will be conducted using the Newcastle Ottawa Scale. Further, narrative synthesis will be conducted as well as a random effect meta-analysis to pool estimates of patient satisfaction and QoL among PLHIV. All statistical analysis will be performed using the R Studio v 4.2.1. Results: Findings from this study will be presented at relevant theme-specific conferences and published in a peer-reviewed journal. Conclusion: Given the global adoption of DTG-based regimens as the mainstay of current treatment guidelines, a comprehensive systematic review focusing on the effects of DTG on patient satisfaction and QoL is required. This study will represent the first study to present the estimates of patient satisfaction levels and QoL among PLHIVs exposed to DTG. Our review will provide a background for clinical decision-making and patient-centred policies. Protocol Registration: This systematic review and meta-analysis protocol was registered on 6 February 2025 on PROSPERO with the identification number, CRD42025643301.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,015 | 0,018 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,011 | 0,004 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».