Impact of Dolutegravir-based regimens on patient satisfaction and quality of life among people living with HIV: A systematic review and meta-analysis protocol
Bibliographic record
Abstract
Introduction: The use of antiretroviral therapy (ART) in HIV management has closed the gap in life expectancies between Persons Living with HIV (PLHIV) and the general populace, leading to longevity among PLHIVs. However, increased life expectancies or longevity do not translate to better treatment satisfaction and Quality of Life (QoL). Available literature indicates a divergence in findings with regards the effect of ART on patient satisfaction levels and QoL. With dolutegravir (DTG)-based regimens currently the mainstay of HIV management, there is the need to ascertain effects of DTG on patient satisfaction and QoL among PLHIV. Thus, the aim of this study is to review the existing literature and pool the patient satisfaction levels and QoL among PLHIV exposed to DTG. Methods: This is a systematic review and meta-analysis. Study outcomes will be the mean values of the QoL, as well as the proportions, odds ratios and risk ratios of patient satisfaction with DTG. Searches will be conducted on PubMed and Scopus databases, with search period limited to the last 10 years. Studies that reported on the effect of DTG on our outcomes of interest will be included. For studies where the study population was exposed to other integrase strand transfer inhibitors or other ART classes, we will collect data separately for the outcomes of those exposed to DTG and those of the comparator. Also, included studies will be peer-reviewed articles that utilized standardized assessment tools to evaluate QoL among PLHIV exposed to DTG. Conversely, this review will exclude case studies, commentaries, editorials, and all forms of reviews. The study will employ the Preferred Reporting Items for Systematic Review and Meta-analysis checklist. Data extraction and screening will be conducted by 4 independent reviewers. Quality assessment will be conducted using the Newcastle Ottawa Scale. Further, narrative synthesis will be conducted as well as a random effect meta-analysis to pool estimates of patient satisfaction and QoL among PLHIV. All statistical analysis will be performed using the R Studio v 4.2.1. Results: Findings from this study will be presented at relevant theme-specific conferences and published in a peer-reviewed journal. Conclusion: Given the global adoption of DTG-based regimens as the mainstay of current treatment guidelines, a comprehensive systematic review focusing on the effects of DTG on patient satisfaction and QoL is required. This study will represent the first study to present the estimates of patient satisfaction levels and QoL among PLHIVs exposed to DTG. Our review will provide a background for clinical decision-making and patient-centred policies. Protocol Registration: This systematic review and meta-analysis protocol was registered on 6 February 2025 on PROSPERO with the identification number, CRD42025643301.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.031 | 0.045 |
| Meta-epidemiology (narrow) | 0.005 | 0.003 |
| Meta-epidemiology (broad) | 0.025 | 0.032 |
| Bibliometrics | 0.010 | 0.008 |
| Science and technology studies | 0.002 | 0.002 |
| Scholarly communication | 0.005 | 0.004 |
| Open science | 0.004 | 0.004 |
| Research integrity | 0.004 | 0.003 |
| Insufficient payload (model declined to judge) | 0.029 | 0.002 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".