RETRACTED: Association of Statin Use and Noninfectious Uveitis

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Retraction Notice This article has been retracted: please see Elsevier policy on article withdrawal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and the authors. Retraction notice to Association of Statin Use and Noninfectious Uveitis: A Systematic Review and Meta-Analysis Tao BK, Butt FR, Dhivagaran T, Mihalache A, Huang RS, Xie JS, Popovic MM, Kaplan AJ. Ophthalmology Retina. 2025. doi:10.1016/j.oret.2025.10.009 The editors and authors wish to note that this article is being retracted from the published record. Following post-publication review, data extraction errors were identified in the primary analysis. Specifically, event counts attributed to Sobrin et al. (1) were erroneously extracted from baseline prevalence figures in the original study rather than from the incident uveitis event counts reported in the results - an error arising from a misplaced decimal point that produced counts inflated by approximately two orders of magnitude (92,525 and 25,167, versus the correct values of 541 and 103, respectively). An additional denominator error was identified in the data extracted from Borkar et al. (2), and study labels were found to be systematically mislabeled in Figures 2 and 4 and in corresponding Results and Discussion text. Upon re-analysis using corrected data, the primary conclusion of the article - that oral statin use was significantly associated with a lower occurrence of noninfectious uveitis - is no longer supported. The corrected primary analysis using unadjusted crude data does not reach statistical significance (OR: 0.91; 95% CI: 0.68-1.21; P = 0.51). Corrected subgroup and leave-one-out sensitivity analyses likewise do not yield statistically significant findings. Following review of the corrected analyses, the editors have determined that the article's primary findings are no longer supportable and that the work is not suitable for continued publication. The authors conducted an internal investigation and affirmed that these errors arose from a traceable and inadvertent failure of the data extraction consensus process and were not the result of any intentional misconduct or data fabrication. Upon identification of these honest errors, all authors were in full agreement of retraction to preserve the veracity of the literature. The authors came forward to acknowledge the errors fully and have cooperated transparently throughout the post-publication review process. The authors sincerely regret and apologize for this unintended outcome. This notice is issued as a retraction of the original article. (1) Sobrin L, Yu Y, Han S, et al. Decreased risk of non-infectious anterior uveitis with statin therapy in a large healthcare claims database. Graefe's Archive for Clinical and Experimental Ophthalmology. 2021;259(9):2783-2793. (2) Borkar DS, Tham VM, Shen E, et al. Association Between Statin Use and Uveitis: Results From the Pacific Ocular Inflammation Study. American Journal of Ophthalmology. 2026/03/31 2015;159(4):707-713.e2.

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