MétaCan
Menu
Back to cohort
Record W4415424531 · doi:10.1016/j.oret.2025.10.009

RETRACTED: Association of Statin Use and Noninfectious Uveitis

2025· review· en· W4415424531 on OpenAlexaff
Brendan Tao, Fahad R. Butt, Thanansayan Dhivagaran, Andrew Mihalache, Ryan S. Huang, Jim Shenchu Xie, Marko M. Popovic, Alexander Kaplan

Post-publication record

OpenAlex flags this work as retracted, but it carries no matching Retraction Watch record in this frame.

Bibliographic record

VenueOphthalmology Retina · 2025
Typereview
Languageen
FieldMedicine
TopicOcular Diseases and Behçet’s Syndrome
Canadian institutionsKensington HealthWestern UniversityUniversity of Toronto
Fundersnot available
KeywordsStatinUveitisHydroxymethylglutaryl-CoA Reductase InhibitorsMEDLINEAssociation (psychology)

Abstract

fetched live from OpenAlex

Retraction Notice This article has been retracted: please see Elsevier policy on article withdrawal (https://www.elsevier.com/about/policies-and-standards/article-withdrawal). This article has been retracted at the request of the Editor-in-Chief and the authors. Retraction notice to Association of Statin Use and Noninfectious Uveitis: A Systematic Review and Meta-Analysis Tao BK, Butt FR, Dhivagaran T, Mihalache A, Huang RS, Xie JS, Popovic MM, Kaplan AJ. Ophthalmology Retina. 2025. doi:10.1016/j.oret.2025.10.009 The editors and authors wish to note that this article is being retracted from the published record. Following post-publication review, data extraction errors were identified in the primary analysis. Specifically, event counts attributed to Sobrin et al. (1) were erroneously extracted from baseline prevalence figures in the original study rather than from the incident uveitis event counts reported in the results - an error arising from a misplaced decimal point that produced counts inflated by approximately two orders of magnitude (92,525 and 25,167, versus the correct values of 541 and 103, respectively). An additional denominator error was identified in the data extracted from Borkar et al. (2), and study labels were found to be systematically mislabeled in Figures 2 and 4 and in corresponding Results and Discussion text. Upon re-analysis using corrected data, the primary conclusion of the article - that oral statin use was significantly associated with a lower occurrence of noninfectious uveitis - is no longer supported. The corrected primary analysis using unadjusted crude data does not reach statistical significance (OR: 0.91; 95% CI: 0.68-1.21; P = 0.51). Corrected subgroup and leave-one-out sensitivity analyses likewise do not yield statistically significant findings. Following review of the corrected analyses, the editors have determined that the article's primary findings are no longer supportable and that the work is not suitable for continued publication. The authors conducted an internal investigation and affirmed that these errors arose from a traceable and inadvertent failure of the data extraction consensus process and were not the result of any intentional misconduct or data fabrication. Upon identification of these honest errors, all authors were in full agreement of retraction to preserve the veracity of the literature. The authors came forward to acknowledge the errors fully and have cooperated transparently throughout the post-publication review process. The authors sincerely regret and apologize for this unintended outcome. This notice is issued as a retraction of the original article. (1) Sobrin L, Yu Y, Han S, et al. Decreased risk of non-infectious anterior uveitis with statin therapy in a large healthcare claims database. Graefe's Archive for Clinical and Experimental Ophthalmology. 2021;259(9):2783-2793. (2) Borkar DS, Tham VM, Shen E, et al. Association Between Statin Use and Uveitis: Results From the Pacific Ocular Inflammation Study. American Journal of Ophthalmology. 2026/03/31 2015;159(4):707-713.e2.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.028
metaresearch head score (Gemma)0.255
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesResearch integrity
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: Editorial
Teacher disagreement score0.988
Threshold uncertainty score0.639

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0280.255
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0050.007
Bibliometrics0.0090.006
Science and technology studies0.0030.002
Scholarly communication0.0100.008
Open science0.0070.004
Research integrity0.0120.011
Insufficient payload (model declined to judge)0.1910.086

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.031
GPT teacher head0.346
Teacher spread0.316 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2025
Admission routes1
Has abstractyes

Explore more

Same venueOphthalmology RetinaSame topicOcular Diseases and Behçet’s SyndromeFrench-language works237,207