Metabolite profiling, cytotoxicity, liver ROS detoxifiers and acetylcholinesterase inhibitors from Trachyandra ciliata L.F. (Kunth) (wild cabbage)
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Notice bibliographique
Résumé
• For the first time, Metabolite profiling, cytotoxicity, liver ROS detoxifiers and acetylcholinesterase inhibitors from Trachyandra ciliata were evaluated in quest to discover more plant-based nutraceuticals for the treatment of chronic diseases. • A total of 71 compounds were observed. • Root extract obtained from 0 mM salinity treatment at 0.5 mg/mL extract concentration showed moderate toxicity to H4IIE- luc cells, while it was non-cytotoxic (> 80 %) to non-cancer cells. • Ethanolic extracts of flower buds from plants grown under 100 mM NaCl and roots from plants grown under 100 and 150 mM NaCl had higher anti-AChE activity. • These findings suggest that T. ciliata could potentially be a therapeutic agent for the treatment of cancer, Alzheimer's disease, and liver disorders. Wild cabbage ( Trachyandra ciliata ) is one of the understudied, wild, edible halophytes from South Africa. Although its edibility has recently been validated, its therapeutic potential was yet to be explored. This research was carried out to profile and characterise the phytochemical content of T. ciliata extracts and evaluate its potential as a therapeutic agent for cancer, acetylcholinesterase (AChE) inhibition and reactive oxygen species (ROS) scavenging in the liver. Cuttings of T. ciliata were grown under 0, 50, 100, 150, and 200 mM salinity concentrations. The ultra-high-performance liquid chromatography mass spectrometry (UHPLC-MS) was employed to quantify and characterise metabolites in leaves, roots, and flower buds of T. ciliata . The yellow dye 3-(4,5-dimethyltiazol-2yl)-2,5-diphenyl tetrazolium bromide (MTT), Ellman's colourimetric method, and the 2′,7′-dichlorodihydrofluorescein diacetate assay (H 2 DCF-DA) were respectively employed to evaluate cytotoxicity, AChE antagonism, and ROS scavenging of the extracts of T. ciliata . A total of 71 compounds were observed, which were grouped into flavonoids, anthocyanins, alkaloids, nucleobase, nucleosides/tide, saccharides, fatty acids, amino acids, and coumarins. A concentration of 1 mg/mL of extracts of T. ciliata flower buds prepared from plants grown at 0 mM and 100 mM salinity, showed strong cytotoxicity to cancer cells, however, the extracts also had moderate and weak cytotoxicity to non-cancer cells. All extracts inhibited AChE activity. Moreover, ROS scavenging was mainly observed primarily in the extracts of leaves from plants grown at all salinities, and in the extract of roots from plants grown at 0 mM salinity treatment. A maiden documentation of anticancer, acetylcholinesterase inhibition, and ROS scavenging activity of crude extracts of T. ciliata was achieved in this study. These findings suggest that T. ciliata could be a potential therapeutic agent for the treatment of cancer, Alzheimer's disease, and liver disorders, amidst the quest to develop more plant-based pharmaceuticals for the treatment of chronic diseases.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,002 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle