Clinical Manifestations and Management of Prurigo in Pregnancy: A Systematic Review
Notice bibliographique
Résumé
A particular type of dermatosis known as prurigo of pregnancy (PP) is typified by highly itchy papulonodules that primarily affect the extremities' extensor surfaces and the hand and feet dorsum. Despite PP not being a rare illness, there is surprisingly a distinct lack of studies exploring its depth. Therefore, this study seeks to thoroughly describe the clinical manifestation and treatment of pregnancy-related prurigo. Additionally, it aims to provide a comprehensive and up-to-date assessment of the effectiveness of different approaches to pregnancy prurigo therapy. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The systematic review searched PubMed, EMBASE, Web of Science, and Cochrane databases from the databases' establishment to 13 August 2024. The studies were deemed included if they were randomized controlled trials (RCTs), cohort studies, case-control, cross-sectional, case series, and case reports; if they reported clinical manifestations and treatment for PP; and if they were written in the English language. Studies were excluded if they did not meet the aforementioned inclusion criteria; moreover, they were excluded if they were of high risk of bias or low quality. The articles included were assessed using the Newcastle-Ottawa scale and methodological quality, and the synthesis of non-randomized studies. Four different studies, with a total of 63 patients, were included in our article. The typical rash of PP is described in most patients with variable onset and distribution on the body, from the extremities to the back to the buttocks. PP can be associated with a variety of conditions, including a history of other skin conditions, such as intrahepatic cholestasis and other medical conditions. Different treatments for PP in pregnant women were reported across the included studies, most commonly a combination of topical steroids, emollients, oral antihistamines, oral corticosteroids, and ultraviolet narrow band (UVB). The effectiveness of the various therapies is variable; some patients recover before delivery, while others recover months postpartum. This systematic review emphasizes how complicated PP is in terms of both its clinical manifestations, associations, and management. The evidence points to the urgent need for a more uniform approach to diagnosis and management due to substantial variability in the clinical features, onset, and treatment responses. The study emphasizes the need for additional, larger-scale research using standardized outcome measures to identify characteristics that predict treatment success and allow for more robust comparisons of treatment modalities.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,005 | 0,023 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,001 |
| Méta-épidémiologie (sens large) | 0,007 | 0,008 |
| Bibliométrie | 0,008 | 0,008 |
| Études des sciences et des technologies | 0,001 | 0,001 |
| Communication savante | 0,002 | 0,002 |
| Science ouverte | 0,002 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,003 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».