Clinical Manifestations and Management of Prurigo in Pregnancy: A Systematic Review
Bibliographic record
Abstract
A particular type of dermatosis known as prurigo of pregnancy (PP) is typified by highly itchy papulonodules that primarily affect the extremities' extensor surfaces and the hand and feet dorsum. Despite PP not being a rare illness, there is surprisingly a distinct lack of studies exploring its depth. Therefore, this study seeks to thoroughly describe the clinical manifestation and treatment of pregnancy-related prurigo. Additionally, it aims to provide a comprehensive and up-to-date assessment of the effectiveness of different approaches to pregnancy prurigo therapy. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The systematic review searched PubMed, EMBASE, Web of Science, and Cochrane databases from the databases' establishment to 13 August 2024. The studies were deemed included if they were randomized controlled trials (RCTs), cohort studies, case-control, cross-sectional, case series, and case reports; if they reported clinical manifestations and treatment for PP; and if they were written in the English language. Studies were excluded if they did not meet the aforementioned inclusion criteria; moreover, they were excluded if they were of high risk of bias or low quality. The articles included were assessed using the Newcastle-Ottawa scale and methodological quality, and the synthesis of non-randomized studies. Four different studies, with a total of 63 patients, were included in our article. The typical rash of PP is described in most patients with variable onset and distribution on the body, from the extremities to the back to the buttocks. PP can be associated with a variety of conditions, including a history of other skin conditions, such as intrahepatic cholestasis and other medical conditions. Different treatments for PP in pregnant women were reported across the included studies, most commonly a combination of topical steroids, emollients, oral antihistamines, oral corticosteroids, and ultraviolet narrow band (UVB). The effectiveness of the various therapies is variable; some patients recover before delivery, while others recover months postpartum. This systematic review emphasizes how complicated PP is in terms of both its clinical manifestations, associations, and management. The evidence points to the urgent need for a more uniform approach to diagnosis and management due to substantial variability in the clinical features, onset, and treatment responses. The study emphasizes the need for additional, larger-scale research using standardized outcome measures to identify characteristics that predict treatment success and allow for more robust comparisons of treatment modalities.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.005 | 0.023 |
| Meta-epidemiology (narrow) | 0.002 | 0.001 |
| Meta-epidemiology (broad) | 0.007 | 0.008 |
| Bibliometrics | 0.008 | 0.008 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".