AMPK in skeletal muscle function and metabolism
Notice bibliographique
Résumé
The FASEB JournalVolume 32, Issue 4 p. 1741-1777 ReviewOpen Access AMPK in skeletal muscle function and metabolism Rasmus Kjøbsted, Corresponding Author Rasmus Kjøbsted rasmus.kjobsted@nexs.ku.dk Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this authorJanne R. Hingst, Janne R. Hingst Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJoachim Fentz, Joachim Fentz Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorMarc Foretz, Marc Foretz INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorMaria-Nieves Sanz, Maria-Nieves Sanz Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland Department of Biomedical Research, University of Bern, Bern, SwitzerlandSearch for more papers by this authorChristian Pehmøller, Christian Pehmøller Internal Medicine Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, USASearch for more papers by this authorMichael Shum, Michael Shum Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorAndré Marette, André Marette Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorRemi Mounier, Remi Mounier Institute NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM Unite 1217, CNRS UMR, Villeurbanne, FranceSearch for more papers by this authorJonas T. Treebak, Jonas T. Treebak Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJørgen F. P. Wojtaszewski, Jørgen F. P. Wojtaszewski Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorBenoit Viollet, Benoit Viollet INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorLouise Lantier, Corresponding Author Louise Lantier louise.lantier@vanderbilt.edu Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee, USA Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this author Rasmus Kjøbsted, Corresponding Author Rasmus Kjøbsted rasmus.kjobsted@nexs.ku.dk Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this authorJanne R. Hingst, Janne R. Hingst Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJoachim Fentz, Joachim Fentz Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorMarc Foretz, Marc Foretz INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorMaria-Nieves Sanz, Maria-Nieves Sanz Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland Department of Biomedical Research, University of Bern, Bern, SwitzerlandSearch for more papers by this authorChristian Pehmøller, Christian Pehmøller Internal Medicine Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, USASearch for more papers by this authorMichael Shum, Michael Shum Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorAndré Marette, André Marette Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorRemi Mounier, Remi Mounier Institute NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM Unite 1217, CNRS UMR, Villeurbanne, FranceSearch for more papers by this authorJonas T. Treebak, Jonas T. Treebak Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJørgen F. P. Wojtaszewski, Jørgen F. P. Wojtaszewski Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorBenoit Viollet, Benoit Viollet INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorLouise Lantier, Corresponding Author Louise Lantier louise.lantier@vanderbilt.edu Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee, USA Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this author First published: 05 January 2018 https://doi.org/10.1096/fj.201700442RCitations: 28AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.— Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism. FASEB J. 32, 1741–1777 (2018). www.fasebj.org ABBREVIATIONS 4E-BP1 4E binding protein 1 ACC2 acetyl-CoA carboxylase 2 AICAR 5-amino-1-β-d-r
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,000 |
| Méta-épidémiologie (sens large) | 0,002 | 0,001 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,001 |
| Communication savante | 0,002 | 0,002 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,002 | 0,003 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,012 | 0,007 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».