AMPK in skeletal muscle function and metabolism
Bibliographic record
Abstract
The FASEB JournalVolume 32, Issue 4 p. 1741-1777 ReviewOpen Access AMPK in skeletal muscle function and metabolism Rasmus Kjøbsted, Corresponding Author Rasmus Kjøbsted rasmus.kjobsted@nexs.ku.dk Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this authorJanne R. Hingst, Janne R. Hingst Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJoachim Fentz, Joachim Fentz Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorMarc Foretz, Marc Foretz INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorMaria-Nieves Sanz, Maria-Nieves Sanz Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland Department of Biomedical Research, University of Bern, Bern, SwitzerlandSearch for more papers by this authorChristian Pehmøller, Christian Pehmøller Internal Medicine Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, USASearch for more papers by this authorMichael Shum, Michael Shum Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorAndré Marette, André Marette Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorRemi Mounier, Remi Mounier Institute NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM Unite 1217, CNRS UMR, Villeurbanne, FranceSearch for more papers by this authorJonas T. Treebak, Jonas T. Treebak Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJørgen F. P. Wojtaszewski, Jørgen F. P. Wojtaszewski Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorBenoit Viollet, Benoit Viollet INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorLouise Lantier, Corresponding Author Louise Lantier louise.lantier@vanderbilt.edu Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee, USA Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this author Rasmus Kjøbsted, Corresponding Author Rasmus Kjøbsted rasmus.kjobsted@nexs.ku.dk Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this authorJanne R. Hingst, Janne R. Hingst Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJoachim Fentz, Joachim Fentz Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorMarc Foretz, Marc Foretz INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorMaria-Nieves Sanz, Maria-Nieves Sanz Department of Cardiovascular Surgery, Inselspital, Bern University Hospital, Bern, Switzerland Department of Biomedical Research, University of Bern, Bern, SwitzerlandSearch for more papers by this authorChristian Pehmøller, Christian Pehmøller Internal Medicine Research Unit, Pfizer Global Research and Development, Cambridge, Massachusetts, USASearch for more papers by this authorMichael Shum, Michael Shum Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorAndré Marette, André Marette Axe Cardiologie, Quebec Heart and Lung Research Institute, Québec, Canada Institute for Nutrition and Functional Foods, Laval University, Québec, CanadaSearch for more papers by this authorRemi Mounier, Remi Mounier Institute NeuroMyoGène, Université Claude Bernard Lyon 1, INSERM Unite 1217, CNRS UMR, Villeurbanne, FranceSearch for more papers by this authorJonas T. Treebak, Jonas T. Treebak Section of Integrative Physiology, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorJørgen F. P. Wojtaszewski, Jørgen F. P. Wojtaszewski Section of Molecular Physiology, Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, DenmarkSearch for more papers by this authorBenoit Viollet, Benoit Viollet INSERM, Unité 1016, Institut Cochin, Paris, France Centre National de la Recherche Scientifique (CNRS), Unité Mixte de Recherche (UMR) 8104, Paris, France Université Paris Descartes, Sorbonne Paris Cité, Paris, FranceSearch for more papers by this authorLouise Lantier, Corresponding Author Louise Lantier louise.lantier@vanderbilt.edu Department of Molecular Physiology and Biophysics, Vanderbilt University, Nashville, Tennessee, USA Mouse Metabolic Phenotyping Center, Vanderbilt University, Nashville, Tennessee, USA Correspondance: Department of Nutrition, Exercise and Sports, Section of Molecular Physiology, Faculty of Science, University of Copenhagen, Universitetsparken 13, DK-2100 Copenhagen, Denmark. E-mail: rasmus.kjobsted@nexs.ku.dk Correspondance: Department of Molecular Physiology and Biophysics, Vanderbilt University, 823 Light Hall, 2215 Garland Ave., Nashville, TN 37232, USA. E-mail: louise.lantier@vanderbilt.eduSearch for more papers by this author First published: 05 January 2018 https://doi.org/10.1096/fj.201700442RCitations: 28AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Skeletal muscle possesses a remarkable ability to adapt to various physiologic conditions. AMPK is a sensor of intracellular energy status that maintains energy stores by fine-tuning anabolic and catabolic pathways. AMPK's role as an energy sensor is particularly critical in tissues displaying highly changeable energy turnover. Due to the drastic changes in energy demand that occur between the resting and exercising state, skeletal muscle is one such tissue. Here, we review the complex regulation of AMPK in skeletal muscle and its consequences on metabolism (e.g., substrate uptake, oxidation, and storage as well as mitochondrial function of skeletal muscle fibers). We focus on the role of AMPK in skeletal muscle during exercise and in exercise recovery. We also address adaptations to exercise training, including skeletal muscle plasticity, highlighting novel concepts and future perspectives that need to be investigated. Furthermore, we discuss the possible role of AMPK as a therapeutic target as well as different AMPK activators and their potential for future drug development.— Kjøbsted, R., Hingst, J. R., Fentz, J., Foretz, M., Sanz, M.-N., Pehmøller, C., Shum, M., Marette, A., Mounier, R., Treebak, J. T., Wojtaszewski, J. F. P., Viollet, B., Lantier, L. AMPK in skeletal muscle function and metabolism. FASEB J. 32, 1741–1777 (2018). www.fasebj.org ABBREVIATIONS 4E-BP1 4E binding protein 1 ACC2 acetyl-CoA carboxylase 2 AICAR 5-amino-1-β-d-r
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.002 | 0.002 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.002 | 0.003 |
| Insufficient payload (model declined to judge) | 0.012 | 0.007 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".