The Impact of Regional Cerebral Oxygen Saturation Monitoring on Elderly Patientswith Hypertension and Debilitation Undergoing LaparoscopicRadical Resection of Gastrointestinal Tumors
Notice bibliographique
Résumé
Objective To investigate the effects of regional cerebral oxygen saturation(rSO2) monitoring and target-oriented management on early cognitive function,inflammatory factors and oxidative stress in elderly patients with hypertension and asthenia after laparoscopic radical resection of gastrointestinal tumors. Methods A total of 80 elderly patients with hypertension and asthenia who planned to undergo laparoscopic radical resection of gastrointestinal tumors under elective general anesthesia and were treated in the People′s Hospital of Xinjiang Uygur Autonomous Region from July 2022 to June 2023 were selected as the study objects,they were divided into 2 groups by random number table method,each group had 40 cases.The control group did not use rSO2 monitoring,while the study group received rSO2 monitoring.Before and after surgery,the scores of the mini-mental state examination(MMSE) and the montreal cognitive assessment(MoCA) were recorded to evaluate the incidence of postoperative cognitive dysfunction(POCD).Serum levels of S100β,neuron specific enolase(NSE),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),superoxide dismutase(SOD) and malondialdehyde(MDA) were measured before and after surgery.The dosage of propofol,remifentanil,sufentanil and vasoactive drugs were recorded during the operation.Numerical rating scale(NRS) was used to evaluate the pain degree of the patients at 2 h,4 h,8 h and 12 h after surgery. Results After one day of surgery,the study group exhibited significantly lower MMSE and MoCA scores compared to their preoperative scores,as well as lower scores than the control group during the same period(P<0.05).Additionally,the incidence of POCD in the study group was significantly lower than that in the control group after one day of surgery(P<0.05).Furthermore,postoperative serum levels of S100β,NSE,IL-6,TNF-α,CRP and MDA were higher in both groups compared to preoperative levels(P<0.05),but these levels were significantly lower in the study group compared to the control group(P<0.05).The SOD levels decreased after one day of surgery in both groups(P<0.05),but remained higher in the study group compared to the control group(P<0.05).Moreover,intraoperatively,propofol and remifentanil consumption was significantly lower in the study group compared to the control group(P<0.05),while there was no significant difference in sufentanil dosage between both groups(P>0.05).The utilization rate of vasoactive drugs was also significantly lower in the study group compared to controls(P<0.05).However,there were no significant differences observed between both groups regarding NRS score at each time point after surgery(P>0.05). Conclusion Monitoring changes in rSO2 and implementing goal-directed management during laparoscopic radical resection of gastrointestinal tumors has a protective effect on early postoperative cognitive function in elderly patients with hypertension and frailty,effectively reducing the secretion of inflammatory factors,oxidative stress response,and risk of POCD.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».