The Impact of Regional Cerebral Oxygen Saturation Monitoring on Elderly Patientswith Hypertension and Debilitation Undergoing LaparoscopicRadical Resection of Gastrointestinal Tumors
Bibliographic record
Abstract
Objective To investigate the effects of regional cerebral oxygen saturation(rSO2) monitoring and target-oriented management on early cognitive function,inflammatory factors and oxidative stress in elderly patients with hypertension and asthenia after laparoscopic radical resection of gastrointestinal tumors. Methods A total of 80 elderly patients with hypertension and asthenia who planned to undergo laparoscopic radical resection of gastrointestinal tumors under elective general anesthesia and were treated in the People′s Hospital of Xinjiang Uygur Autonomous Region from July 2022 to June 2023 were selected as the study objects,they were divided into 2 groups by random number table method,each group had 40 cases.The control group did not use rSO2 monitoring,while the study group received rSO2 monitoring.Before and after surgery,the scores of the mini-mental state examination(MMSE) and the montreal cognitive assessment(MoCA) were recorded to evaluate the incidence of postoperative cognitive dysfunction(POCD).Serum levels of S100β,neuron specific enolase(NSE),interleukin-6(IL-6),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),superoxide dismutase(SOD) and malondialdehyde(MDA) were measured before and after surgery.The dosage of propofol,remifentanil,sufentanil and vasoactive drugs were recorded during the operation.Numerical rating scale(NRS) was used to evaluate the pain degree of the patients at 2 h,4 h,8 h and 12 h after surgery. Results After one day of surgery,the study group exhibited significantly lower MMSE and MoCA scores compared to their preoperative scores,as well as lower scores than the control group during the same period(P<0.05).Additionally,the incidence of POCD in the study group was significantly lower than that in the control group after one day of surgery(P<0.05).Furthermore,postoperative serum levels of S100β,NSE,IL-6,TNF-α,CRP and MDA were higher in both groups compared to preoperative levels(P<0.05),but these levels were significantly lower in the study group compared to the control group(P<0.05).The SOD levels decreased after one day of surgery in both groups(P<0.05),but remained higher in the study group compared to the control group(P<0.05).Moreover,intraoperatively,propofol and remifentanil consumption was significantly lower in the study group compared to the control group(P<0.05),while there was no significant difference in sufentanil dosage between both groups(P>0.05).The utilization rate of vasoactive drugs was also significantly lower in the study group compared to controls(P<0.05).However,there were no significant differences observed between both groups regarding NRS score at each time point after surgery(P>0.05). Conclusion Monitoring changes in rSO2 and implementing goal-directed management during laparoscopic radical resection of gastrointestinal tumors has a protective effect on early postoperative cognitive function in elderly patients with hypertension and frailty,effectively reducing the secretion of inflammatory factors,oxidative stress response,and risk of POCD.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".