Assessing the oxidative status of individuals with the metabolic syndrome : before, during and after the consumption of milled flaxseed or flaxseed oil
Notice bibliographique
Résumé
The global prevalence of Type 2 Diabetes Mellitus (T2DM) has increased exponentially over the last few decades.In Canada, the prevalence of T2DM was 7.2% in 1995 and is estimated tobe 9.2%oby 2025.Diabetes mellitus is associated with an increased flux of reactive oxygen species and an alteration in the cellular redox system that results in a loss of reducing capacity, with repercussion on antioxidant defense system.The human body has a complex antioxidant defense system that includes the antioxidant enzymes superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) along with the non-enzymatic antioxidants like Vitamin E, C, A, flavanoids and p-carotene.Flaxseed is one of the richest sources of a-linolenic acid (^LA-52%), and the lignan, secoisolariciresinol diglucoside (SDG-0.6-1.8%), which has the antioxidant activity of inhibiting lipid peroxidation and scavenging produced free radicals specially hydroxyl radical.The effect of consuming flaxseed and flaxseed oil in people with T2DM has not been studied.Subjects were recruited in accordance with the initial objective of the study of assessing the oxidative status among individuals having T2DM, after consuming milled flax and flax oil in food products.Parameters like their fasting blood glucose and glycated haemoglobin did not support that these subjects had T2DM during the study.Additionally other parameters like lipid profile, waist to hip ratio and BMI, supported that these subjects had metabolic syndrome according ot the def,rnition of the WHO (World Health Organization) and NCEP:ATP III Q.{ational Cholesterol Education :Fr-Progranr: Adult Treatment Panel III).Metabolic syndrome is characterized by an aggregation of metabolic risk factors present in an individual putting them at an increased risk of developing pathologic conditions including diabetes mellitus.Biochemical parameters measured to assess oxidative status were plasma antioxidants Vitamins A (retinol) &.E by HPLC, and Vitamin C by Omey's spectrophotometeric assay.Total plasma antioxidant property was determined by the Ferric reducing antioxidant property assay (FRAP); plasma hydroperoxides were analyzed by FOX 2 assay and urinary isoprostanes were estimated with kits from Caymen Chemicals.CAT and SOD activity were determined by the assay described by Aebi and Spitz, respectively, using a UV spectrophotometer.Results revealed no signif,rcant changes among the parameters measured for the different study groups.The antioxidants Vitamins A, E & C were unaltered and FRAP values were in the normal range of healthy adults for all the groups.No significant difference was observed in plasma hydroperoxide and urinary isoprostane levels between the groups consuming either milled flax or flax oil.There was no effect of flaxseed supplementation on erythrocyte SOD or CAT activity.In conclusion, flaxseed supplementation to subjects with metabolic syndrome showed no effect on oxidative status.Flaxseed did not increase or decrease the indices of lipid peroxidation in these subjects.Hence, focus should be directed on the possibility that flaxseed may be important or effective in intemrpting the pathologic process rather than being given when there is no pathologic condition present.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».