Carbon nanotube based targeted drug delivery systems for breast cancer and other drug delivery applications
Notice bibliographique
Résumé
Breast cancer is the most commonly diagnosed cancer in women and the second leading cause of death among all cancers. Surgical removal of breast tumour tissues is the primary treatment for breast cancer. However, this does not rule out relapse at local or distant sites, so, chemotherapy is widely used as an adjuvant therapy. Although effective, chemotherapy drugs often cause severe side effects due to their non-specificity to cancer cells. Nanotechnology for drug delivery is an emerging field focused on targeting drugs to the desirable sites, such as tumour tissues, while minimizing the unwanted side effects of chemotherapy drugs on other tissues. Discovery of a new type of nanomaterial opens more opportunities for drug delivery. The carbon nanotube (CNT) is a novel type of synthetic material that has shown great potential for targeted delivery of anti-cancer agents. The initial hurdle for biomedical applications of CNT has been its hydrophobicity. Proper surface modification of CNT, or CNT functionalization, so as to prepare well-dispersed and biocompatible CNT in biologically compatible solutions, is a primary step for its biomedical application. In this thesis, noncovalent functionalization of CNT using various polymers is first explored to make well-dispersed CNT. By identifying the problems of the existing CNT-based drug delivery systems, three novel schemes for CNT-based, targeted drug delivery systems are designed and developed for delivery of a potent breast cancer chemotherapy drug paclitaxel (PTX). The three CNT-PTX delivery systems are characterized and evaluated for their toxicity, drug-loading capacity, cell penetration and cancer cell growth inhibition in vitro. Of the three schemes, the CNT-drug carrier developed through a lipid-drug approach is the best delivery system in terms of drug loading capacity, targeted drug delivery features and potential multifunctional drug delivery. Hence, the CNT-lipid-drug delivery system has been selected for further evaluation for its in vivo tumour growth inhibition, safety and toxicity using a breast cancer xenograft mice model. The CNT-lipid-drug approach has shown good results in a breast cancer animal model. Overall, this thesis explores a new type of nanomaterial as a drug carrier to overcome major limitations of chemotherapy drugs. As a newly discovered nanomaterial, research on CNT as a drug carrier is still in its infancy. Each of these schemes offers a new route of drug loading on CNT, which contributes to our present knowledge on construction of CNT-based drug delivery systems.
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Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,000 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».