Determinants of Bacillus Calmette-Guérin (BCG) vaccination among Québec children
Notice bibliographique
Résumé
ABSTRACTIntroduction:A province-wide non-mandatory tuberculosis prevention program offered free Bacillus Calmette-Guérin (BCG) vaccination to neonates and schoolchildren in the province of Québec (1949-1974). It has been suggested that BCG vaccination rates in Québec varied by geographical area, yet little is known about other determinants. Objectives:To identify determinants of BCG vaccination among Québec children born in 1974, considering separately vaccination occurring during the systematic vaccination program and after the program. Methods:A retrospective birth cohort, the Québec Birth Cohort on Immunity and Health (QBCIH), was assembled by including 81,496 subjects born in the province of Québec (Canada) in 1974 after at least 32 weeks of gestation. Analyses of potential determinants as documented in the Birth Registry and Healthcare Registration File were conducted among 71,658 individuals (88% of cohort) with complete data. Additional sociodemographic and other characteristics were assessed on 1643 subjects who participated in a telephone interview in 2012 (1154 interviewed individuals with complete information). Odds ratios (OR) and 95% confidence intervals (CI) were computed from logistic regression, with best models selected from backward elimination. For each of the two sources of data (administrative databases and interviews), separate regression models were constructed for the two outcomes: vaccination during and after the organized program. Finally, models considering the variables from both sources, as selected in previous steps, were estimated among 1320 interviewed participants with complete information for these variables.Results:Forty-six percent of the study subjects were BCG vaccinated, 42.8% within the program and 3.6% after it ended. During the vaccination program, children whose parents were born outside of Québec were less likely to be BCG vaccinated than those with Québec-born parents [OR=0.38, 95% CI: 0.20-0.75 for mothers; OR=0.25, 95% CI: 0.14-0.46 for fathers], and urban inhabitants had a lower likelihood of vaccination compared with rural dwellers [OR=0.50, 95% CI: 0.38-0.65]. When the mass BCG vaccination program was discontinued, children whose grandparents were not all of French ancestry were less likely to be BCG vaccinated than those whose grandparents were all of French ancestry [OR=0.40, 95% CI: 0.19-0.84]. Conclusion:This is the first study comprehensively investigating determinants of BCG vaccination in Québec, Canada. Different factors were identified as being related to vaccination within and after the organized program.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,004 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».