Determinants of Bacillus Calmette-Guérin (BCG) vaccination among Québec children
Bibliographic record
Abstract
ABSTRACTIntroduction:A province-wide non-mandatory tuberculosis prevention program offered free Bacillus Calmette-Guérin (BCG) vaccination to neonates and schoolchildren in the province of Québec (1949-1974). It has been suggested that BCG vaccination rates in Québec varied by geographical area, yet little is known about other determinants. Objectives:To identify determinants of BCG vaccination among Québec children born in 1974, considering separately vaccination occurring during the systematic vaccination program and after the program. Methods:A retrospective birth cohort, the Québec Birth Cohort on Immunity and Health (QBCIH), was assembled by including 81,496 subjects born in the province of Québec (Canada) in 1974 after at least 32 weeks of gestation. Analyses of potential determinants as documented in the Birth Registry and Healthcare Registration File were conducted among 71,658 individuals (88% of cohort) with complete data. Additional sociodemographic and other characteristics were assessed on 1643 subjects who participated in a telephone interview in 2012 (1154 interviewed individuals with complete information). Odds ratios (OR) and 95% confidence intervals (CI) were computed from logistic regression, with best models selected from backward elimination. For each of the two sources of data (administrative databases and interviews), separate regression models were constructed for the two outcomes: vaccination during and after the organized program. Finally, models considering the variables from both sources, as selected in previous steps, were estimated among 1320 interviewed participants with complete information for these variables.Results:Forty-six percent of the study subjects were BCG vaccinated, 42.8% within the program and 3.6% after it ended. During the vaccination program, children whose parents were born outside of Québec were less likely to be BCG vaccinated than those with Québec-born parents [OR=0.38, 95% CI: 0.20-0.75 for mothers; OR=0.25, 95% CI: 0.14-0.46 for fathers], and urban inhabitants had a lower likelihood of vaccination compared with rural dwellers [OR=0.50, 95% CI: 0.38-0.65]. When the mass BCG vaccination program was discontinued, children whose grandparents were not all of French ancestry were less likely to be BCG vaccinated than those whose grandparents were all of French ancestry [OR=0.40, 95% CI: 0.19-0.84]. Conclusion:This is the first study comprehensively investigating determinants of BCG vaccination in Québec, Canada. Different factors were identified as being related to vaccination within and after the organized program.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.004 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".