Motoric cognitive risk syndrome: cognitive profile and association with cardio vascular diseases and risk factors
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Résumé
Motoric Cognitive Risk (MCR) syndrome is a pre-dementia syndrome, which has been associated with cardiovascular diseases and risk factors (CVDRF) in the US, Japan and pooled multi country populations.The cognitive profile of individuals with MCR syndrome is unknown.Our objectives were: 1) To examine and compare the cognitive performances of non-demented older community-dwellers with and without MCR and Mild Cognitive Impairment (MCI) syndromes, 2) To determine whether MCR syndrome was associated with CVDRF in French, older community-dwellers, and 3) To quantitatively synthesize, with a systematic review and meta-analysis, the association of MCR syndrome with CVDRF.Methods.To further explore these research objectives, we performed 2 studies: Objective 1 was examined in study 1, objectives 2 and 3 in study 2. A cross-sectional database was used.The Gait and Alzheimer Interactions Tracking (GAIT) study is a French database with a total of 912 French community dweller participants from November 2009 to May 2016.After applying the inclusion criteria, a total of 291 nondemented individuals (18.2% diagnosed with MCR) were included in study 1.Cognitive performances were measured using the scores of Mini-Mental Status Examination (MMSE), Frontal Battery Assessment (FAB), Free and Cued Selective Reminding Test (FCRST), Trail Making Test part A (TMTA) and B (TMTB) and Stroop test.In study 2, a meta-analysis was also conducted with Medline and Embase in February 2017 using the terms "motoric cognitive risk syndrome" OR "motoric cognitive risk" OR "motoric risk", with 3.5% (or 7 of 202) studies selected.After applying the inclusion criteria, a total of 238 older community-dwellers non-demented (71.43.6 years; 37.4% female), of which 16.8% were diagnosed with MCR were examined in the original part of the second study.Results.The prevalence of MCI was higher in the MCR group.Moreover, multiple linear regressions showed that these (MCI and MCR) individuals performed worse on all cognitive tests (P<0.005),except the ratio part III /part I of Stroop (P=0.471).Worst performance for this group was for the MMSE score (effect size = -0.57[95% Confidence Interval (CI): -1.02;-0.12])and for TMTB (effect size = 0.59 [95% CI: 0.14;1.04]).Abnormal waist hip ratio (Odd ratio -OR) >2.8 with P<0.020) and high blood pressure (OR >2.5 with P<0.025) were associated with MCR.In the meta-analysis, all pooled OR were significant with P-value <0.001 (OR = 1.41 for cardiovascular diseases, 1.21 for hypertension, 1.44 for diabetes, 2.05 for stroke and 1.34 for obesity).The overall OR was 1.38 (95% CI, 1.33-1.45)with P-value<0.001,for all pooled CVDRF. Conclusion.MCR syndrome is significantly associated with low global cognitive performance and CVDRF.Moreover, the association of MCR and MCI syndromes is highly prevalent and characterized by a worsening cognitive performance.
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Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,001 | 0,001 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,005 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle