The influence of steroid and peptide hormones on cognition and mood during late pregnancy and early postpartum
Notice bibliographique
Résumé
Cognitive and mood changes during pregnancy and postpartum have been subjectively reported by women and have also been objectively measured. However, evidence relating to the relationship between hormone levels and these changes is sparse and contradictory. The studies presented in this thesis were undertaken to investigate the possible influence of estradiol (E2), progesterone (P), testosterone (T), cortisol (CORT) and prolactin (PRL) levels on cognitive functioning and mood during late pregnancy and the early postpartum period. In Study 1, pregnant women were tested on a battery of neuropsychological tests once during late pregnancy and once during the early postpartum period and their scores were compared to non-pregnant controls. Results showed that the pregnancy group had significantly lower scores than the controls on tasks of verbal recall and processing speed both during the pregnancy and the postpartum test times. CORT levels were significantly associated, in an inverted-U function, with verbal recall scores during pregnancy and postpartum and with spatial abilities at postpartum. During pregnancy, negative linear associations were observed between PRL and executive function and paragraph recall scores along with an inverted-U association with paragraph recall scores. At postpartum, E2 and CORT were negatively associated, in a linear fashion, with attention scores. In Study 2, linear and non-linear associations between hormones and mood during pregnancy and postpartum were investigated while taking into consideration psychosocial factors previously found to be related to mood changes during these reproductive periods. Perceived stress, social support from friends, social support from a significant other and sleep were found to be significant predictors of mood scores. During pregnancy, a small positive linear correlation was obtained between levels of PRL and lower mood scores. At the postpartum visit, moderate U-shaped correlations were found between mood disturbances and level of E2 and P while smaller increases in the Cortisol Awakening Response were associated with poorer mood. Collectively, the present studies provide new evidence that aspects of cognitive function and mood are altered during pregnancy and the postpartum periods and may be modulated, at least in part, by hormonal and psychosocial factors during these reproductive events.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction machine sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Le volet Gemma est une étiquette directe du modèle pour chaque travail de la base, lue sur la notice réduite au titre. Le volet Codex est un classifieur appris des 10 348 étiquettes directes de Codex et calibré sur les taux pondérés de l'échantillon; les champs sans appui suffisant ne portent aucun appel Codex. Le mode candidate est l'union des deux volets; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont pas des étiquettes humaines.
Scores du classifieur distillé par catégorie (deux têtes)
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule source (Gemma direct ou Codex distillé), pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».