Use of non-steroidal anti-inflammatory drugs and statins, and risk of prostate cancer in Montreal
Notice bibliographique
Résumé
Objective: Non steroidal anti-inflammatory drugs (NSAIDs) and statins are associated with many solid tumours. We conducted a case-control study among French-speaking Montrealers (Canada) to estimate associations with use of NSAIDs or statins, and risk of prostate cancer.Methods : Data were collected from patients (n=1,429) aged 40 to 75 years, ascertained across the 11 major French hospitals in the Montreal Metropolitan area, newly diagnosed with prostate cancer between September 1, 2005 and December 31, 2010. Controls (n=1,543) were selected from the general population, were registered on Quebec's permanent electoral list as French speakers, resident in the Montreal Metropolitan area, were from the same electoral districts as cases, and were frequency-matched to cases by age (±5 years). Unconditional logistic regression with adjustment for potential confounding variables was used to estimate odds ratios and 95% confidence intervals.Of the 2,972 subjects, 204 (6.9 %) were NSAID users, 589 (19.9 %) were daily low dose users of aspirin, and 415 (14 %) were statins users. Ever use of NSAIDs (adjusted OR = 1.22; 95% CI: 0.88-1.69) was not associated with prostate cancer risk. Likewise, current use or duration of use was also not associated with risk of prostate cancer. However, a self-reported history of using NSAID between 6-10 years before the reference date was inversely associated with prostate cancer risk (OR=0.43; 95% CI: 0.21-0.89). Use of daily low dose of aspirin was not significantly associated with prostate cancer (OR=1.02; 95% CI 0.85-1.24). Nonetheless, 18 % reduced risk of developing prostate was found with time since first use (2-5 years before reference date). There was no association between statin use and risk of prostate cancer (OR=1.20; 95% CI: 0.90-1.60). By contrast, men who had self-reported to have used statins for more than five years were positively associated with prostate cancer risk (OR=1.56; 95% CI: 1.07-2.27). Conclusion: Overall this study provides no strong evidence of either causation or prevention of prostate cancer by NSAIDs or daily low dose of aspirin or statin. However, timing in exposure and duration of use might have biological implications in the relation between these medications and prostate cancer risk.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».