Cyclooxygenase and CD147 expression in human and feline oral squamous cell carcinoma
Notice bibliographique
Résumé
Many investigators have provided evidence supporting the role of chronic inflammation in the development and progression of many types of cancer, including oral squamous cell carcinoma (OSCC). OSCC is a highly invasive and aggressive malignancy that occurs in humans and in animals. OSCC is the sixth most common cancer in people, with an estimated 4600 new cases in Canada in 2016, and 1250 deaths. One of the ways that inflammation can contribute to cancer progression is by promoting tumour cell invasiveness. Human OSCC has been found to have increased expression of CD147. It is a known mediator of invasive behavior that has been suggested as a possible target for cancer therapy. Cyclooxygenases (COX-1 and COX-2) are important mediators of inflammation that are up regulated in OSCC and other cancers. A relationship between inflammation and CD147 in cancer was recently proposed in hypopharyngeal human carcinoma. Similar to the situation in humans, OSCC is the most common tumour in the oral cavity of cats and is very aggressive with an average survival of only 2-4 months. Studies have shown that COX-2 is expressed in feline OSCC and COX inhibitors are used as part of OSCC treatment in cats. Studying feline OSCC provides an opportunity to learn about core mechanisms of this disease shared between species, possibly revealing treatment strategies that may help patients. Cats provide an excellent opportunity for studying OSCC as they are an outbred, diverse animal population that suffers from aggressive disease and quick disease progression. The objective of this project was to determine if there is a positive relationship between the cyclooxygenase pathway of inflammation and CD147 expression in feline and human OSCC. Evaluation of immunohistochemistry results showed that a subset of human and feline OSCC patients express COX-2 and CD147. This finding was confirmed in three human and three feline OSCC cell lines using RT-qPCR, which showed varying expression of COX-1, COX-2 and CD147. Additionally, the human and feline OSCC cell lines secreted PGE2 into culture medium. A significant relationship between COX-2 and CD147 expression was not revealed in either species, but it was found that COX-1 may be a source of tumour derived PGE2 and may serve as a therapeutic target for some human and feline patients. Additionally, this is the first report of CD147 expression in a feline malignancy. The role of CD147 in feline tumour progression warrants further study, and pet cats with OSCC may present an opportunity to evaluate future CD147-targeted therapies.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».