?lseratif kolitli hastalarda g?zlenen inflamasyonda Srage'nin olas? antiinflamatuvar rol?n?n ayd?nlat?lmas?
Pourquoi ce travail est dans la base
Une base qui oublie comment elle a trouvé un travail ne peut pas être vérifiée. Voici les voies qui ont admis celui-ci.
Notice bibliographique
Résumé
?lseratif Kolit (?K) ve Crohn Hastal??? (CH) gibi etyolojisi tam olarak a??klanamam?? bir grup hastal?ktan olu?an ?nflamatuvar Ba??rsak Hastal?klar? (?BH) ay?r?c? tan?s?n?n yap?labilmesi, tedavisinin d?zenlenmesi ve prognozunun takibi i?in ?o?u zaman endoskopi gibi giri?imsel y?ntemlere gereksinim duyulmaktad?r. Bu nedenle kolay saptanabilecek yeni biyolojik belirte?lere gereksinim vard?r. ?BH mekanizmas?nda, bir multiligand resept?r olan `ileri glikasyon son ?r?nleri resept?r?? (RAGE) ve onun ??z?n?r formu `sRAGE?nin ad? ge?mektedir. sRAGE ve onun ligandlar?ndan biri olan kalprotektin, intestinal mukozada eksprese edilerek hem ba??rsak l?menine hem de dola??ma sal?nmaktad?r. Bu proteinlerin serum ve mukozadaki de?i?imini ayd?nlatmak i?in ?K?li hastalar ?al??maya al?nm??t?r. sRAGE, hem inflamatuvar hem de non-inflamatuvar mukozada Western blot tekni?i kullan?larak; serum sRAGE ve kalprotektin de `Enzyme-linked immunosorbent assay? (ELISA) y?ntemiyle ?l??lm??t?r. Kolonoskopi yap?lan hastalar Montreal s?n?flamas?na g?re alt gruplara ayr?lm??, serum belirte?leri ve mukozal sRAGE d?zeyleri a??s?ndan gruplar aras?nda anlaml? fark saptanmam??t?r. Ayr?ca ?K?li hastalar?n inflame ve non-inflame mukozalar? aras?nda da fark bulunmam??t?r. ?K?li hastalar?n kolonoskopi yard?m?yla iyi tan?mlanm?? alt grubunda serum sRAGE ve kalprotektin anlaml? d???k bulunmu?tur. Bu ?al??ma, s?n?rl? say?da hastayla yap?lm??t?r ve inflamatuvar belirte?ler aras?ndaki ili?kiyi ayd?nlatmakta yetersiz kalmaktad?r. Bu belirte?lerin d?zeyleri aras?ndaki ili?kinin ara?t?r?laca?? daha ileri ?al??malar?n yap?lmas? gerekmektedir. Ulcerative Colitis (UC) and Crohn Disease are classified as Inflammatory Bowel Diseases (IBD) and their etiology is not fully elucidated. Since the diagnosis and therapy of IBD require the use of invasive methods such as endoscopy, a new biological marker which can easily be determined is needed. A multiligand receptor called Receptor of Advanced Glycation End Products (RAGE) and its soluble form (sRAGE) are involved in the mechanism of IBD. sRAGE and one of its ligands, calprotectin, are expressed in intestinal mucosa and secreted both to the bowel lumen and the blood circulation. Patients with UC were subjected to this study in order to clarify the alteration of those proteins in the bowel mucosa and the serum. sRAGE was measured with Western blotting both in the inflammatory and the non-inflammatory bowel mucosa samples, and the serum sRAGE and calprotectin levels were measured with Enzyme-linked immunosorbent assay (ELISA). The UC patients that had colonoscopy were divided into subgroups according to the Montreal classification and no statistical difference was found between the serum and mucosal samples of subgroups. We also couldn?t find any statistical difference between the inflammed and the non-inflammed bowel mucosa samples of the UC patients. However, both sRAGE and calprotectin serum levels were significantly lower at the subgroup of UC which was well defined by endoscopy. This study was carried out with limited number of samples and is not sufficient enough to elucidate the interactions between the iflammatory markers and IBD. Further investigations with greater number of samples should be carried out.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,002 | 0,002 |
| Méta-épidémiologie (sens large) | 0,002 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,001 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,002 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,001 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découle