?lseratif kolitli hastalarda g?zlenen inflamasyonda Srage'nin olas? antiinflamatuvar rol?n?n ayd?nlat?lmas?
Bibliographic record
Abstract
?lseratif Kolit (?K) ve Crohn Hastal??? (CH) gibi etyolojisi tam olarak a??klanamam?? bir grup hastal?ktan olu?an ?nflamatuvar Ba??rsak Hastal?klar? (?BH) ay?r?c? tan?s?n?n yap?labilmesi, tedavisinin d?zenlenmesi ve prognozunun takibi i?in ?o?u zaman endoskopi gibi giri?imsel y?ntemlere gereksinim duyulmaktad?r. Bu nedenle kolay saptanabilecek yeni biyolojik belirte?lere gereksinim vard?r. ?BH mekanizmas?nda, bir multiligand resept?r olan `ileri glikasyon son ?r?nleri resept?r?? (RAGE) ve onun ??z?n?r formu `sRAGE?nin ad? ge?mektedir. sRAGE ve onun ligandlar?ndan biri olan kalprotektin, intestinal mukozada eksprese edilerek hem ba??rsak l?menine hem de dola??ma sal?nmaktad?r. Bu proteinlerin serum ve mukozadaki de?i?imini ayd?nlatmak i?in ?K?li hastalar ?al??maya al?nm??t?r. sRAGE, hem inflamatuvar hem de non-inflamatuvar mukozada Western blot tekni?i kullan?larak; serum sRAGE ve kalprotektin de `Enzyme-linked immunosorbent assay? (ELISA) y?ntemiyle ?l??lm??t?r. Kolonoskopi yap?lan hastalar Montreal s?n?flamas?na g?re alt gruplara ayr?lm??, serum belirte?leri ve mukozal sRAGE d?zeyleri a??s?ndan gruplar aras?nda anlaml? fark saptanmam??t?r. Ayr?ca ?K?li hastalar?n inflame ve non-inflame mukozalar? aras?nda da fark bulunmam??t?r. ?K?li hastalar?n kolonoskopi yard?m?yla iyi tan?mlanm?? alt grubunda serum sRAGE ve kalprotektin anlaml? d???k bulunmu?tur. Bu ?al??ma, s?n?rl? say?da hastayla yap?lm??t?r ve inflamatuvar belirte?ler aras?ndaki ili?kiyi ayd?nlatmakta yetersiz kalmaktad?r. Bu belirte?lerin d?zeyleri aras?ndaki ili?kinin ara?t?r?laca?? daha ileri ?al??malar?n yap?lmas? gerekmektedir. Ulcerative Colitis (UC) and Crohn Disease are classified as Inflammatory Bowel Diseases (IBD) and their etiology is not fully elucidated. Since the diagnosis and therapy of IBD require the use of invasive methods such as endoscopy, a new biological marker which can easily be determined is needed. A multiligand receptor called Receptor of Advanced Glycation End Products (RAGE) and its soluble form (sRAGE) are involved in the mechanism of IBD. sRAGE and one of its ligands, calprotectin, are expressed in intestinal mucosa and secreted both to the bowel lumen and the blood circulation. Patients with UC were subjected to this study in order to clarify the alteration of those proteins in the bowel mucosa and the serum. sRAGE was measured with Western blotting both in the inflammatory and the non-inflammatory bowel mucosa samples, and the serum sRAGE and calprotectin levels were measured with Enzyme-linked immunosorbent assay (ELISA). The UC patients that had colonoscopy were divided into subgroups according to the Montreal classification and no statistical difference was found between the serum and mucosal samples of subgroups. We also couldn?t find any statistical difference between the inflammed and the non-inflammed bowel mucosa samples of the UC patients. However, both sRAGE and calprotectin serum levels were significantly lower at the subgroup of UC which was well defined by endoscopy. This study was carried out with limited number of samples and is not sufficient enough to elucidate the interactions between the iflammatory markers and IBD. Further investigations with greater number of samples should be carried out.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.017 | 0.005 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".