THE LINKS BETWEEN CIRCADIAN CLOCK DISRUPTION AND LIFESTYLE TRAITS IN RHEUMATOID ARTHRITIS
Notice bibliographique
Résumé
Background: Rheumatoid Arthritis (RA) is an inflammatory autoimmune disease that affects people worldwide. Emerging studies have proposed a key role of circadian clock system in RA. Lifestyle traits such as dietary intake and cigarette smoking can trigger and/or influence RA progression. This study hypothesizes that lifestyle traits could modulate the circadian clock system leading to an impact on the severity and progression of rheumatoid arthritis. Accordingly, optimizing the circadian rhythms through lifestyle interventions may benefit rheumatoid arthritis patients. Methods: The study was conducted in two parts: a preclinical study using RA-like animal model and a cross-sectional population study using 2017-2018 Canadian Community Health Survey (CCHS) data. The preclinical part involved two interventions i.e., Western Diet (WD) and cigarettes smoking (SMK) and our goal was to compare their effect on RA-like animal model groups (WTR, WTR-WD and WTR-SMK) healthy control groups (WTH, WTH-WD, WTH-SMK). The circadian profile and disease severity were assessed using wheel running activity and clinical scoring/histological evaluation, respectively. Mice were sacrificed at four timepoints (N=3/timepoints) to assess the peripheral clock gene expressions. The population study analyzed the relationships between arthritis and lifestyle traits. We also examined the association between lifestyle traits and arthritis-related outcomes in individuals with arthritis. Results: Wheel running activity and clock genes expression indicated a significant change in groups fed with western diet and in groups exposed to cigarette smoking. The change was more pronounced in RA-like animals (WTR-WD and WTR-SMK). Disease progression evidenced by clinical score did not differ significantly between groups, however, histological evaluation showed a more severe tissue damage in WTR-WD and WTR-SMK groups. The population study analysis indicated a significant association between arthritis and diminished sleep quality, and poorer general and mental health. Moreover, a healthy dietary pattern and non-smoking status were associated with better general health and refreshing sleep in individuals with arthritis. However, not all investigated dimensions of sleep health were positively associated. Conclusions: Overall the research findings highlight the impact of examined lifestyle traits on both central and peripheral circadian clock which can have detrimental effects on health outcomes and disease progression in rheumatoid arthritis. These findings carry significant implications and a better understanding of the links, and the underlying molecular mechanisms could help with the clinical management of the disease and improvement of disease outcomes.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,001 |
| Études des sciences et des technologies | 0,001 | 0,000 |
| Communication savante | 0,000 | 0,001 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».