Limitations in physical performance in people with chronic obstructive pulmonary disease
Notice bibliographique
Résumé
People with chronic obstructive pulmonary disease (COPD) show deficits in physical performance, including skeletal muscle dysfunction (atrophy, weakness), and activity limitation due to fatigue, dyspnea, and pain. Little is known about the pattern of pain and muscle dysfunction and how they impact physical performance in people with COPD. Based on the components of the International Classification of Functioning, Disability and Health (i.e. body structure, body function, and activity limitation), the purposes of this thesis were to examine patients with COPD to determine: 1) thigh muscle shape and size changes; 2) the severity, interference, and characteristics of pain; 3) how comorbidities relate to pain; 4) the relationships between pain and physical performance (muscle strength, walk distance, and daily physical activity). Methods and Results: Three sets of cross-sectional experiments were performed. Study 1: Size and shape descriptors derived from magnetic resonance imaging of thighs were compared in COPD patients to healthy people. Muscle atrophy and shape changes were common and non-uniformly distributed among individual thigh muscles compared to healthy people (Chapter 2). Study 2: A survey study demonstrated that pain severity and interference (measured by the McGill Pain Questionnaire and Brief Pain Inventory) were higher in people with COPD compared to age- and gender-matched controls (n=47 per group). The number of comorbidities was an independent correlate of pain severity in COPD (Chapter 3). A second analysis of the survey data was performed on a larger sample of COPD patients who experienced pain (n=54) further explored the pattern of comorbidities and pain. The number of comorbidities was associated with pain severity and interference; musculoskeletal and endocrine conditions contribute to pain severity; and people with COPD were under-treated for pain (Chapter 4). Study 3: This cross-sectional study demonstrated that pain was associated with a lower six-minute walk test, shorter active and standing times, and longer sedentary times (measured by three-dimensional accelerometry), and increased body mass index (Chapter 5). In summary, regional muscle atrophy might contribute to deficits in muscle performance in people with COPD. In addition, pain is significant in people with COPD and can be considered as an activity-limiting factor in COPD.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».