Effect of Cucumis Callosus Fruit Extract on the Kidney Function of DMBA-Induced Mammary Cancer in Female Albino Wistar Rats
Notice bibliographique
Résumé
Breast cancer is currently one of the most prevalently diagnosed cancers and the 5th cause of cancer-related deaths with an estimated number of 2.3 million new cases worldwide according to the GLOBOCAN 2020 data.Treatment and management therapies for cancer are expensive and hardly affordable by patients in developing and underdeveloped countries.This study aimed at investigating the effect of Cucumis callosus fruit extract on the kidney function of DMBA-induced mammary cancer in female albino Wistar rats.The study utilized the extract of mature, fresh, healthy pulp of Cucumis Callosus fruits.Thirty-six (36) healthy Adult female Wistar Albino rats weighing about 150 to 200g were organized into 5 groups: The groups in which the rats were categorized into are as follows: Group 1:Standard diet + water only; Group 2: Induced intravenously with 0.01% DMBA without treatment; Group 3: Induced with 0.01% DMBA + treatment with standard drug; Group 4: Induced with 0.01% DMBA + 100mg/b.wtCucumis callosus fruit extract; Group 5: Induced with 0.01% DMBA + 200mg/b.wtCucumis callosus fruit extract.Rats administered a single dose of DMBA orally per body weight.The serum samples of the rats were analyzed for various kidney function parameters including creatinine, bicarbonate, urea, sodium, potassium, and chloride using a UV/ visible spectrophotometer.The data obtained were analyzed statistically using One-Way Analysis of Variance (ANOVA).The significance between means was determined at a p-value of less than 0.05 (p<0.05).The results for each treatment were presented as mean ± standard deviation.The result of serum creatinine concentrations obtained in this study showed a significant (P<0.05)reduction in Group 5 rats (21.1 mmol/L) upon administering 200mg/b.wtCucumis callosus fruit extract to the rats induced with 0.01% DMBA compared to the group of experimental rats induced with cancer without treatment.Serum urea concentration was highest in Group 2 (36.35 mmol/L) which represents the set of rats induced 0.01% DMBA without treatment.However, serum urea concentration was significantly (p<0.05)reduced in Group 5 rats (16.89 mmol/L) upon administering 200mg/b.wtCucumis callosus fruit extract to the rats induced with 0.01% DMBA compared to all other groups besides the control group.In this study, administration of Cucumis callosus fruit extract significantly lowered serum sodium concentration across the groups (P<0.05)compared to Group 2 experimental rats which had high concentration of sodium possibly caused by cancer induction.Findings from this study revealed that Cucumis callosus fruit extract therapy did not provide statistically significant improvements in serum chloride, potassium, and bicarbonate levels.However, Cucumis callosus fruit extract therapy was found effective in ameliorating the poor renal function of the cancer-induced female Wistar rats.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,002 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».