Dynamics of brain neurotrophic factor levels in children with motor development delays in early intervention
Notice bibliographique
Résumé
Annotation. Delayed motor development in early childhood is a common problem that affects a child's motor and cognitive skills, as well as their future quality of life. The aim of the study was to assess the dynamics of brain-derived neurotrophic factor (BDNF) levels in children with motor development delay before the implementation of an individualized comprehensive early intervention program and one month after, with a view to determining the potential role of BDNF as a biomarker of neuroplasticity. The study included 56 children aged 7-8 months with motor development delay. The children were divided into two subgroups: 28 full-term children with motor development delay and 28 premature children with motor development delay, taking into account their corrected age. The control group consisted of 25 healthy children aged 7-8 months without motor disorders. The early intervention program included motor development exercises, sensory integrative therapy, and training for parents to work with their children on a daily basis. The study lasted 1 month. To evaluate the effectiveness of the early intervention program, the dynamics of motor skill development were analyzed using the Alberta Infant Motor Scale (AIMS) and the BDNF level in blood serum. For statistical analysis, quantitative indicators were described using median (Me) and interquartile range (IQR). Comparisons between three independent groups were performed using the nonparametric Kruskal-Wallis test. Comparisons between two dependent groups were performed using the nonparametric Wilcoxon test at p<0.05. At the beginning of the study, the AIMS assessment showed a gradual decrease in motor development from the control group to full-term children with delayed motor development and the lowest scores in premature children, reflecting a progressive increase in the severity of motor deficits. One month after early intervention, both groups showed an increase in median motor skill scores, with a statistically significant difference between the study groups after rehabilitation (p<0.001). At the beginning of the study, BDNF levels differed statistically in all groups. The lowest and consistently low scores in the group of premature infants indicate reduced neuroplasticity in premature infants with motor disorders. Under the influence of early intervention, after 1 month, there were significant changes in BDNF in two groups, which may indicate the potential effectiveness of rehabilitation programs in stimulating neuroplastic processes, and BDNF can be considered a sensitive marker for assessing the dynamics of motor function recovery.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,001 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,001 | 0,001 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».