Serum Pentosidine as a Biomarker of Osteoporosis and Fracture
Notice bibliographique
Résumé
Osteoporosis, by definition, is the loss of bone mass and bone strength. Its development is driven by changes in the structure and tissue composition of bone. Women tend to experience these changes to a greater extent than men. Fractures can be catastrophic for an elderly individual with osteoporosis. Fractures affect an individual’s mobility, self-care, quality of life and are associated with an increased risk of death. A debilitating sub-type of osteoporotic fracture is the atypical femur fracture or AFF. AFFs preferentially affect women and are associated with long-term use of antiresorptive osteoporosis medications. Because of this association, it has been suggested that AFFs are the result of structural or mineralization changes in bone. It is unclear why some individuals who take antiresorptive therapy experience AFF while others do not. Advanced glycation end-products (AGEs) are proteins or lipids that have been non-enzymatically glycated. AGEs have been implicated in many degenerative diseases and aging. In bone, AGE accumulation makes bones brittle and may contribute to fracture incidence. Pentosidine (PEN) is an AGE which has been implicated in bone fragility. Bone PEN and serum PEN are linearly correlated and elevations in both are associated with fracture. PEN is an attractive potential biomarker of osteoporosis, fracture and AFF and assessment of serum PEN may provide insight into how systemic changes in AGEs may relate to skeletal changes with aging. Thus, this thesis aimed to explore the association between serum PEN, osteoporosis and fracture, particularly AFF. A cohort of women in the Canadian Multicentre Osteoporosis Study were used to investigate the possible associations between serum PEN, osteoporosis and fracture. We found that serum PEN was not associated with a diagnosis of osteoporosis but was associated with fragility fracture. A series of case-control studies were then conducted and found that elevated serum PEN is associated with AFF. Collectively, these analyses suggest that AGEs play a role in fracture and likely affect bone quality. However, the effect of AGEs may only be relevant for a portion of the osteoporotic population. Further characterization of AGEs is warranted as they may emerge as a useful AFF screening tool.
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Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,000 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,000 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,000 | 0,000 |
| Intégrité de la recherche | 0,001 | 0,000 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,001 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».