Notice bibliographique
Résumé
In the Dutch population of Golden retrievers, a predisposition for the development of cancer in general and certain types of cancer (such as mast cell tumours and possibly also soft tissue sarcomas (STS)) was shown to exist. In addition, age, location and incidence of various tumours differed as related to the diagnostical procedure of choice, being either cytology or histology, indicating a selection bias for diagnostic procedure. A subset of the collected cohort, consisting of unclassified sarcomas, (n=110) were selected for revision. Revision was based on morphological characteristics and, if deemed necessary, additional immunohistochemistry. In 58 tumours, we were able to arrive at the diagnosis of a specific STS. As many as 31 tumours (28%), however, were on revision not considered to be STS. Four neoplasms (4%) were considered non-neoplastic. These numbers illustrate the necessity for revision (and \\ possibly subclassification) of this group of tumours. \n \nDNA-aneuploidy may reflect a malignant nature of mesenchymal proliferations and herald gross genomic instability. Of all mesenchymal tumours examined within this study, half of all sarcomas were aneuploid. Benign mesenchymal neoplasms were rarely aneuploidy, and all of the inflammatory lesions were diploid. The determination of DNA ploidy status is considered to be of additional value when attempting to better differentiate between malignant and non-malignant mesenchymal lesions. In addition, hypoploidy appears more common in canine sarcomas and hyperploid cases show less deviation of the DNA index than human sarcomas. This strengthens the concept of interspecies variation in the evolution of gross chromosomal aberrations during cancer development. \n \nAiming to identify genes causing the suspected breed predispositionfor the development of STS in both the Labrador- and Golden retriever breed,a genome-wide association study was performed. Results were suggestive for a germ-line genetic connection between the development of STS in the Labrador- and Golden retriever breed. Within both breeds, different loci (all of which contained candidate genes already known to be involved in the development of cancer) could be identified. \nThe histiocytic sarcoma is a specific sarcoma subtype that often develops in Flatcoated retrievers. Within this tumour, the significantly altered expression of nine genes and deregulation of gene signaling pathways were identified by means of a microarray study and additional q PCR confirmation. These genes were not yet implicated in histiocytic sarcoma manifestations in the dog nor in comparable human histiocytic/dendritic sarcomas. \nHistiocytic sarcomas can be grouped mainly into a soft tissue- and visceral form. The Flatcoated retriever is predisposed mainly for the first subtype. Genetic differences possibly causing the phenotypical variation of these two histiocytic sarcoma subtypes were identified by microarray analyses. The significantly aberrant expression of three genes were confirmed by q PCR. These differences indicate that these two forms of histiocytic sarcoma in the dog display a variation in gene expression.
Récupéré en direct depuis OpenAlex et désinversé. Les résumés ne sont pas conservés dans cette base de données : les index inversés représentent 8,6 Go des 9,3 Go de texte de la base, et le serveur dispose de 13 Go libres.
Comment cette classification a été obtenuedéplier
Prédiction distillée sur la base complète
Imitation des enseignantsNi prévalence calibrée, ni vérité terrain. Validation humaine à venir. Apprise à partir de 10 348 étiquettes directes de Codex et de 10 348 étiquettes directes de Gemma. Le mode candidate est l'union des têtes enseignantes seuillées; le consensus est leur intersection. Ces sorties portent le statut machine_predicted_unvalidated et ne sont ni des étiquettes humaines ni des étiquettes directes de modèles de pointe.
Scores Codex et Gemma par catégorie
| Catégorie | Codex | Gemma |
|---|---|---|
| Métarecherche | 0,001 | 0,000 |
| Méta-épidémiologie (sens strict) | 0,000 | 0,000 |
| Méta-épidémiologie (sens large) | 0,001 | 0,000 |
| Bibliométrie | 0,000 | 0,000 |
| Études des sciences et des technologies | 0,000 | 0,000 |
| Communication savante | 0,000 | 0,000 |
| Science ouverte | 0,001 | 0,001 |
| Intégrité de la recherche | 0,000 | 0,001 |
| Charge utile insuffisante (le modèle a refusé de juger) | 0,000 | 0,000 |
Scores machine (provisoires)
Les deux têtes enseignantes du modèle étudiant, lues sur ce travail. Un score ordonne la base pour la relecture; il n'affirme jamais une catégorie, et le statut de validation accompagne chaque rangée tel quel.
Scores de référence d'un modèle non mature (critères de maturité non atteints, 7 itérations). Un score ordonne; il n'affirme jamais une catégorie.
score_only:v0-immature-baseline · tel quel depuis la passe de notation : score_only signifie que le nombre peut ordonner les travaux, et qu'aucune étiquette de catégorie n'en découleClassification
machine, non validéePrédiction automatique; un appel candidat d’une seule tête enseignante, pas un consensus.
Le détail, modèle par modèle et score par score, se trouve en fin de page sous « Comment cette classification a été obtenue ».