Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
2010· article· en· Nature Genetics· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
1 650
citations
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Reduced H3K27me3 and DNA Hypomethylation Are Major Drivers of Gene Expression in K27M Mutant Pediatric High-Grade Gliomas
2013· article· en· Cancer Cell· Medicine
affsans résumé
842
citations
EZH2 Is Required for Germinal Center Formation and Somatic EZH2 Mutations Promote Lymphoid Transformation
2013· article· en· Cancer Cell· Biochemistry, Genetics and Molecular Biology
affsans résumé
841
citations
The Paf1 Complex Is Required for Histone H3 Methylation by COMPASS and Dot1p: Linking Transcriptional Elongation to Histone Methylation
2003· article· en· Molecular Cell· Biochemistry, Genetics and Molecular Biology
affsans résumé
713
citations
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
2010· article· en· Blood· Biochemistry, Genetics and Molecular Biology
afffund
597
citations
The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset
2011· article· en· Nature· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
558
citations
Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia
2012· article· en· Nature Medicine· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
526
citations
An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1
2013· article· en· ACS Chemical Biology· Biochemistry, Genetics and Molecular Biology
aff
466
citations
The histone lysine methyltransferase KMT2D sustains a gene expression program that represses B cell lymphoma development
2015· article· en· Nature Medicine· Biochemistry, Genetics and Molecular Biology
affsans résumé
443
citations
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
2009· article· en· Nature Genetics· Biochemistry, Genetics and Molecular Biology
affsans résumé
415
citations
COMPASS, a Histone H3 (Lysine 4) Methyltransferase Required for Telomeric Silencing of Gene Expression
2002· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
aff
412
citations
Epigenetic Regulation by Histone Methylation and Histone Variants
2005· review· en· Molecular Endocrinology· Biochemistry, Genetics and Molecular Biology
afffund
328
citations
EZH2 mutations are frequent and represent an early event in follicular lymphoma
2013· article· en· Blood· Biochemistry, Genetics and Molecular Biology
aff
323
citations
EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis
2010· article· en· Blood· Biochemistry, Genetics and Molecular Biology
aff
297
citations
Catalytic site remodelling of the DOT1L methyltransferase by selective inhibitors
2012· article· en· Nature Communications· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
286
citations
A key role for EZH2 and associated genes in mouse and human adult T-cell acute leukemia
2012· article· en· Genes & Development· Biochemistry, Genetics and Molecular Biology
aff
259
citations
EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
2016· article· en· Cancer Cell· Biochemistry, Genetics and Molecular Biology
affsans résumé
250
citations
Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
2017· article· en· Nature Genetics· Biochemistry, Genetics and Molecular Biology
affsans résumé
243
citations
TrxG and PcG Proteins but Not Methylated Histones Remain Associated with DNA through Replication
2012· article· en· Cell· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
242
citations
EZH2 inhibition activates a dsRNA–STING–interferon stress axis that potentiates response to PD-1 checkpoint blockade in prostate cancer
2021· article· en· Nature Cancer· Immunology and Microbiology
affsans résumé
241
citations
A Vertebrate Polycomb Response Element Governs Segmentation of the Posterior Hindbrain
2009· article· en· Cell· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
239
citations
Determination of enriched histone modifications in non-genic portions of the human genome
2009· article· en· BMC Genomics· Biochemistry, Genetics and Molecular Biology
fundno aff
238
citations
The Expression of Endothelial Nitric-oxide Synthase Is Controlled by a Cell-specific Histone Code
2005· article· en· Journal of Biological Chemistry· Biochemistry, Genetics and Molecular Biology
aff
234
citations
Selective inhibition of EZH2 and EZH1 enzymatic activity by a small molecule suppresses MLL-rearranged leukemia
2014· article· en· Blood· Biochemistry, Genetics and Molecular Biology
aff
230
citations
DNA methylation in ES cells requires the lysine methyltransferase G9a but not its catalytic activity
2008· article· en· The EMBO Journal· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
229
citations