The evolving role of natural products in drug discovery
2005· review· en· Nature Reviews Drug Discovery· Medicine
affsans résumé
2 555
citations
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Acarbose for prevention of type 2 diabetes mellitus: the STOP-NIDDM randomised trial
2002· article· en· The Lancet· Medicine
affsans résumé
2 548
citations
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
2019· review· en· The Lancet Neurology· Medicine
affsans résumé
2 541
citations
Endocrine Regulation of Energy Metabolism by the Skeleton
2007· article· en· Cell· Biochemistry, Genetics and Molecular Biology
affsans résumé
2 541
citations
Global carbon dioxide emissions from inland waters
2013· article· en· Nature· Earth and Planetary Sciences
affsans résumé
2 541
citations
Pembrolizumab in patients with advanced hepatocellular carcinoma previously treated with sorafenib (KEYNOTE-224): a non-randomised, open-label phase 2 trial
2018· article· en· The Lancet Oncology· Medicine
affsans résumé
2 536
citations
Testing the pecking order theory of capital structure
2002· article· en· Journal of Financial Economics· Business, Management and Accounting
affsans résumé
2 536
citations
The potential and challenges of nanopore sequencing
2008· review· en· Nature Biotechnology· Engineering
affsans résumé
2 533
citations
Defining trained immunity and its role in health and disease
2020· review· en· Nature reviews. Immunology· Immunology and Microbiology
affsans résumé
2 527
citations
Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
2019· review· en· Nature Genetics· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
2 526
citations
Allostatic load biomarkers of chronic stress and impact on health and cognition
2009· review· en· Neuroscience & Biobehavioral Reviews· Neuroscience
affsans résumé
2 515
citations
Ground water and climate change
2012· article· en· Nature Climate Change· Earth and Planetary Sciences
affsans résumé
2 515
citations
Guidelines for Performing a Comprehensive Transthoracic Echocardiographic Examination in Adults: Recommendations from the American Society of Echocardiography
2018· article· en· Journal of the American Society of Echocardiography· Medicine
aboutno affsans résumé
2 502
citations
Progress and problems with the use of viral vectors for gene therapy
2003· review· en· Nature Reviews Genetics· Biochemistry, Genetics and Molecular Biology
fundno affsans résumé
2 501
citations
A flat Universe from high-resolution maps of the cosmic microwave background radiation
2000· article· en· Nature· Physics and Astronomy
affsans résumé
2 499
citations
Climatological mean and decadal change in surface ocean pCO<sub>2</sub>, and net sea-air CO<sub>2</sub> flux over the global oceans
2009· article· en· HAL (Le Centre pour la Communication Scientifique Directe)· Earth and Planetary Sciences
affsans résumé
2 498
citations
Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper
2009· article· en· Journal of the American College of Cardiology· Medicine
affsans résumé
2 497
citations
Evolution and classification of the CRISPR–Cas systems
2011· review· en· Nature Reviews Microbiology· Biochemistry, Genetics and Molecular Biology
affsans résumé
2 496
citations
Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer
2017· article· en· Cell· Medicine
affsans résumé
2 495
citations
Glial and neuronal control of brain blood flow
2010· review· en· Nature· Biochemistry, Genetics and Molecular Biology
afffundsans résumé
2 492
citations
Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study
2020· article· en· The Lancet Oncology· Medicine
affsans résumé
2 492
citations
Gut–brain axis: how the microbiome influences anxiety and depression
2013· review· en· Trends in Neurosciences· Biochemistry, Genetics and Molecular Biology
affsans résumé
2 485
citations
New ICD-10 version of the Charlson comorbidity index predicted in-hospital mortality
2004· article· en· Journal of Clinical Epidemiology· Health Professions
affsans résumé
2 484
citations
Genetics of rheumatoid arthritis contributes to biology and drug discovery
2013· review· en· Nature· Medicine
afffundsans résumé
2 473
citations
2 469
citations