Abstract 8500: Alcohol Effect on Incident Atrial Fibrillation in Individuals with Cardiovascular Disease: Analysis of Data from the ONTARGET and TRANSCEND Studies
Bibliographic record
Abstract
The relationship of alcohol consumption with atrial fibrillation (AF) is inconsistent, and little is known about the impact of alcohol intake on AF incidence in older people with cardiovascular diseases (CVD) or diabetes. The purpose of this analysis is to assess the association between alcohol consumption and incident AF among older individuals with CVD or diabetes mellitus with end organ damage. A cohort of individuals (n=30,430) without AF at baseline, aged ≥55 years, with established CVD or high risk diabetes mellitus, and participating in two randomized trials, the ONTARGET or TRANSCEND (median follow-up of 56 months), were included in the analysis. Alcohol intake was classified as low (Group 1, <1 drink/week, referent), medium (Group 2, 1-14 drinks/week for women and 1-21 drinks/week for men) and high (Group 3, >14 drinks/week for women or >21 drinks/week for men) consumption, according to the World Health Organization recommendations. Multivariable Cox regression was used to model the relationship between alcohol intake and incident AF. There were 2093 new onset AF events in these patients. The age- and sex-standardized incidence rates were 14.47, 17.29 and 20.89 events per 1000 person years in Group 1, 2 and 3, respectively with an additional 6.42 events per 1000 person years in high compared to low alcohol consumers. The unadjusted and adjusted hazard ratios of incident AF associated with alcohol intake were shown in the Table. A significant linear dose response relationship was found (p for trend <0.0001 and =0.0019, respectively in the unadjusted and full-adjusted models). In conclusion, moderate alcohol intake is associated with an increased incidence of AF in older individuals with CVD or diabetes mellitus and in a linear fashion with increasing consumption. Recommendations made about the protective effects of moderate alcohol intake in patients at high risk of CVD should be tempered with this new finding.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.006 | 0.006 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.004 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".