Crohn's disease phenotype, prognosis, and long-term complications: what to expect?
Bibliographic record
Abstract
According to Montreal classification, different phenotypes of Crohn's disease are defined taking into account age at diagnosis, localization of digestive lesions at first surgery, and cumulative anatomical behaviour. This classification is supported by the increased severity of the disease when diagnosed in childhood, the relative stability of disease localization over time, and the clinical importance of intestinal complications as stricture and abscess or fistula formation. However, type and delay of complications are dependent on disease localization (they develop early in small bowel disease and late in colitis), every patient will develop complications one day, and perianal disease may be an important problem observed in up to half the patients. The percentage of patients with active disease every year remains stable, about 40%, after the 3 first years, and only a few patients have long periods of remission. Intestinal resections are required in the majority of patients during life, and many are operated on several times. Prognosis is hampered by iterative surgery, cancer and side-effects of treatment. Standardized mortality ratio is 1.50. Although occurrence of complications, need for surgery and mortality did not change significantly through the years 1950-2000, there are some signals suggesting that new therapetic strategies (immunosuppressants earlier in high risk patients) and biologics will modify natural history and improve the long-term prognosis.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.016 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.003 | 0.001 |
| Bibliometrics | 0.002 | 0.002 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.003 | 0.005 |
| Open science | 0.002 | 0.001 |
| Research integrity | 0.005 | 0.003 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".