Assessment of the contribution of various Ca <sup>2+</sup> /Calcineurin‐regulated NFAT isoforms to the process of skeletal muscle fiber remodelling
Bibliographic record
Abstract
Calcineurin (Cn) is a Ca 2+ ‐regulated serine/threonine phosphatase that acts on the Nuclear Factor of Activated T‐cells (NFAT) family of transcription factors. Involvement of the Cn/NFAT signaling pathway in the modulation of the skeletal muscle fiber phenotype is recognized, however, the role of the various Cn‐regulated NFAT isoforms (NFATc1‐c3) in this modulation is still emerging. We thus assessed the expression and function of each NFAT factor in muscle fibers from wild type or transgenic NFATc2‐ or NFATc3‐deficient mice under normal weightbearing or functional work overload conditions. Using immunofluorescent nuclear colocalization assays and RT‐PCR analysis, we show that normal weight bearing mice harbouring mutant NFAT isoforms display compensatory increases of surviving NFAT family members that may act as surrogates to maintain a semblance of the original muscle phenotype. On the other hand, when muscles of NFAT mutant mice were functionally overloaded the phenotype remodeling associated with this model was differentially prevented suggesting distinct roles for NFATc1‐c3 in response to various functional challenges. (Funded by NSERC, CIHR and CRC to RNM)
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".