Nesfatin‐1 Stimulates Stress Hormone Secretion
Bibliographic record
Abstract
Cellular actions of nesfatin‐1 on oxytocin (OT), vasopressin (AVP) and corticotropin releasing factor (CRF) neurons (J Neuroendocrinol 20:255,2008), the activation of early gene expression in those types of neurons following stress (Brain Res 1300:114,2009), and the ability of nesfatin‐1 to elicit fear and anxiety behaviors (Psychopharmacol 201:115,2008; AJP 297:R330,2009) suggested a role for nesfatin‐1 in the stress response. In conscious, unrestrained male rats i.c.v. administration of 180 pmole nesfatin‐1 resulted in significant increases in plasma levels of AVP (vehicle: 1.9±0.5, n=8; nesfatin‐1: 10.0±3.4 pg AVP/ml, n=8, p = 0.018) and ACTH (vehicle: 6.0±1.4; nesfatin‐1: 28.5±7.7 pg ACTH/ml; p<0.01) 10 minutes later. Plasma OT levels were unchanged. The actions of nesfatin‐1 on food intake and cardiovascular function are dependent upon activation of POMC neurons (AJP 297:R330,2009) and roles for OT in those actions have been reported. We suggest that nesfatin‐1 activates stress hormone secretion by releasing AVP and CRF but that the ability of nesfatin‐1 to activate OT neurons reflects an action to release OT centrally and not into the peripheral plasma.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".