Characterization of the Expression and Function of Chemerin and CMKLR1 within the Central Nervous System
Bibliographic record
Abstract
Adipose derived signaling molecules (adipokines) play a crucial role in regulating satiety, metabolic homeostasis and body weight via endocrine actions in the CNS. We have identified a novel adipokine, chemerin, which regulates adipogenesis and adipose metabolism through actions on the chemokine‐like receptor 1 (CMKLR1). In the present study the neurological localization of chemerin and CMKLR1 mRNA was determined by dissecting mouse brains into cortex, brain stem, hypothalamus and pituitary. Similar levels of CMKLR1 mRNA expression were detected in each of the brain regions. Conversely, chemerin mRNA expression was enriched in the pituitary. Expression of both genes was significantly reduced in hypothalamus and pituitary of obese (Ob/Ob) mice. In vitro studies confirmed CMKLR1 and chemerin co‐expression in mouse hypothalamus and pituitary cell lines. Immunofluorescence corroborates this data identifying CMKLR1 expression on the hypothalamic cell membrane. These findings suggest that chemerin and CMKLR1 may represent a novel endocrine pathway that is functionally important in the brain centers that regulate feeding and metabolism. Funding: CIHR, NSHRF, DMRF, DPEF
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".