5‐aminoimidazole‐4‐carboxamide‐1‐β‐D‐ribofuranoside (AICAR) alters in vitro vasomotor responses of thoracic aorta rings from spontaneously hypertensive (SHR) and Wistar‐Kyoto (WKY) rats
Bibliographic record
Abstract
AICAR has been shown to reduce systolic blood pressure in hypertensive rats and to activate endothelial nitric oxide synthase in cultured cells. However, the effects of in vitro AICAR treatment on isolated vessel vasomotor function are unknown. Aortic rings were isolated from 16–20wk old male SHR and WKY rats and assessed using myography in order to determine potential vasomotor effects of AICAR. Relaxation to increasing concentrations of acetylcholine (ACh) was abolished in SHR vessels pre‐exposed to AICAR (2mM, 30min pre‐incubation, −AICAR=97±6%, +AICAR=−32±5%, p<0.01) but only partially inhibited in WKY rings (−AICAR=98%±8, +AICAR= 43±11%, p<0.01, strain∗drug p<0.01) at maximum [ACh] (10 −4 M). AICAR produced a right‐ward shift in the dose‐response curve generated with sodium nitroprusside in vessels from both rat strains (logEC 50 for SHR: −AICAR=−9.3, +AICAR=−8.6, p<0.01, WKY: −AICAR=−9.2, +AICAR=−8.0, p<0.01, strain∗drug p=0.05). In other experiments, rings were preconstricted with phenylephrine (10 −7 M) and dilation to acute AICAR (2mM) was determined to be 64±12% (p<0.01) and 27±9% (p<0.01) in SHR and WKY rings respectively. Further work is required to understand the mechanisms by which AICAR directly or indirectly affects the vasomotor function in both SHR and WKY vessels and possible reasons for the strain differences to AICAR. Funded by the Heart and Stroke Foundation of Ontario
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".