Dysregulated Expression Of Renal Epithelial Sodium Channels (ENaC) In Dahl Rats.
Bibliographic record
Abstract
ENaC plays an important role in Na transport. Effects of high salt diet on α, β and γ ENaC expression in Dahl S vs R rats has not yet been studied. S and R rats were fed regular [rs, 0.3%] or high [hs, 8%] salt for 2 weeks. mRNA and protein expression in kidney were studied by qRT-PCR and immunoblotting and cellular distribution assessed by immunohistochemistry. In cortex, hs increased β and γ mRNA and protein in R but decreased β protein in S. γ protein was lower in S than R. Cellular distribution was not affected. In medulla, ENaC mRNA abundance was similar in S and R on rs;hs increased β and γ mRNA but not protein in R medulla and decreased α protein abundance in inner medulla (IM). Protein abundance in S was ~2fold higher than R: for α and β in outer medulla (OM) and for γ in IM. Apical staining of all subunits was more in IM collecting ducts of S than R. 2 weeks hs further increased γ protein and apical staining in IM of S. These results indicate strain dependent regional ENaC regulation by hs. S appear to have greater ENaC abundance in IM which might contribute to Na retention.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".