Dysregulated Expression Of Renal Epithelial Sodium Channels (ENaC) In Dahl Rats.
Bibliographic record
Abstract
ENaC plays an important role in Na transport. Effects of high salt diet on α, β and γ ENaC expression in Dahl S vs R rats has not yet been studied. S and R rats were fed regular [rs, 0.3%] or high [hs, 8%] salt for 2 weeks. mRNA and protein expression in kidney were studied by qRT-PCR and immunoblotting and cellular distribution assessed by immunohistochemistry. In cortex, hs increased β and γ mRNA and protein in R but decreased β protein in S. γ protein was lower in S than R. Cellular distribution was not affected. In medulla, ENaC mRNA abundance was similar in S and R on rs;hs increased β and γ mRNA but not protein in R medulla and decreased α protein abundance in inner medulla (IM). Protein abundance in S was ~2fold higher than R: for α and β in outer medulla (OM) and for γ in IM. Apical staining of all subunits was more in IM collecting ducts of S than R. 2 weeks hs further increased γ protein and apical staining in IM of S. These results indicate strain dependent regional ENaC regulation by hs. S appear to have greater ENaC abundance in IM which might contribute to Na retention.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".