Neurogenetic variations in enhanced perceptual vividness are linked to differences in task-related brain activity
Bibliographic record
Abstract
Growing evidence suggests that emotional stimuli are not only better remembered than mundane ones, but that affective salience alters their perception. In a previous study, we demonstrated that emotional events are perceived with the subjective experience of enhanced perceptual vividness, or EEV as assessed with a visual magnitude estimation task (Fig. 1) (Todd et al., 2012). More recently, we were able to show that marked individual differences in EEV can be partly explained by a genetic polymorphism in the ADRA2b gene associated with altered norepinephrine levels. Participants genotyped for the ADRA2b deletion variant had to estimate the magnitude of random noise overlaid on emotionally salient and neutral pictures while fMRI data was collected. EEV is indexed by the extent to which observers rate more emotionally arousing images as containing less overlaid noise, reflecting greater signal-to-noise ratio for the underlying image. Blood oxygenation level-dependent (BOLD) response was analyzed using a novel multivariate approach (Hunter and Takane, 2002). Constrained principle component analysis (CPCA) allows detection of those components or brain networks that account for most of the variance in the data that is directly related to the task. The analysis revealed that ADRA2b deletion carriers show higher activity in general task- and attention-related brain regions such as the visual cortex and parietal regions (Fig. 2). Moreover, EEV modulated activity in a network involving salience-related brain regions such as ACC, the caudate nucleus and early visual areas (Fig. 3) reflecting behavioral findings of greater EEV in ADRA2b deletion carriers. The present study underlines the effectiveness of CPCA to detect task-related brain networks. The findings suggest that common genetic differences linked to norepinephrine influence both brain activity related to overall attention to the magnitude estimation task and EEV modulated activity of salience related brain regions linked to subjective experience of emotionally enhanced perceptual vividness. Meeting abstract presented at VSS 2015
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".