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Record W128165906

Glucose regulation and brain aging.

2000· article· en· W128165906 on OpenAlexaff
Claude Messier, Marc‐André Gagnon

Bibliographic record

VenuePubMed · 2000
Typearticle
Languageen
FieldMedicine
TopicDiet and metabolism studies
Canadian institutionsUniversity of Ottawa
Fundersnot available
KeywordsImpaired glucose toleranceMedicineDiabetes mellitusType 2 diabetesBlood sugar regulationPopulationInternal medicineEndocrinologyDisease
DOInot available

Abstract

fetched live from OpenAlex

Blood glucose regulation is not only a complex phenomenon but glucose regulatory levels also vary significantly across individuals. Thus, whereas individuals compromised with moderately elevated blood glucose levels are diagnosed as having impaired glucose tolerance, excessive blood glucose levels render a Type II diabetes diagnosis. Type II diabetes prevalence rates in the adult population have been estimated to be between 6 and 10 percent. Although Type II diabetes has been typically associated with older people, the disease has become much more common among young adults and children. It has become increasingly evident that protracted glucose tolerance impairment usually precedes a type II diabetes diagnosis, although impaired glucose tolerance will not necessarily progress to a diabetic state. Furthermore, a number of studies have shown that impaired glucose tolerance or type II diabetes is associated with impaired cognitive function in older subjects. In addition, we recently found that cognitive deficits are also associated with moderately impaired glucose regulation in young healthy volunteers. These data, although in need of confirmation and extension, suggest that impaired glucose tolerance is associated with impaired cognition, independent of age. Moreover, since impaired glucose tolerance is more prevalent than diabetes across all ages, then our finding lead to the implication that impaired cognitive function may be more prevalent in the general population than previously estimated. Finally, the dysfunction of glucoregulatory mechanisms may be an important intervening factor when studying the evolution of cognitive function through the aging process.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.006
Threshold uncertainty score0.019

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0010.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0060.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.016
GPT teacher head0.233
Teacher spread0.217 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations43
Published2000
Admission routes1
Has abstractyes

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