Inhibition of colonic cancer cell proliferation and COX2 by oats avenanthramides (Avns).
Bibliographic record
Abstract
High intake of whole grain foods is associated with reduced risk of colon cancer, but the mechanism underlying this protection has yet to be elucidated. Avns are polyphenols unique to oats. We have reported that Avns inhibited pro‐inflammatory cytokines and vascular smooth muscle cell proliferation. We have also discovered that methyl ester of Avns‐C (CH3‐Avn‐C) has more potency. Chronic inflammation may lead to the increased risk of colon cancer. Here, we report the inhibitory effect of Avns on proliferation and expression of COX2 in colonic cancer cell lines. We found that Avns of oat extract and CH3‐Avn‐C significantly inhibited proliferation of several colonic cancer cell lines in the magnitude order of HCT116>CaCo2>LS174>HT29. In contrast, they had no effect on the differentiated CaCo2 cells, which represent the normal colonic epithelial cells. TNFα‐induced COX2 expression and prostaglandin E2 production in HT29 cells were decreased by these compounds. They also suppressed the phosphorylation of the p65 subunit of NF‐κB in this cell line. Our data suggest for the first time that Avns have anti‐inflammatory and anti‐proliferative effects on colonic cancer cell lines. Supported by USDA agreement No. 58‐1950‐9‐001.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".