Enantioselective α-Trifluoromethylation of Aldehydes via Photoredox Organocatalysis
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Abstract
The first enantioselective, organocatalytic alpha-trifluoromethylation and alpha-perfluoroalkylation of aldehydes have been accomplished using a readily available iridium photocatalyst and a chiral imidazolidinone catalyst. A range of alpha-trifluoromethyl and alpha-perfluoroalkyl aldehydes were obtained from commercially available perfluoroalkyl halides with high efficiency and enantioselectivity. The resulting alpha-trifluoromethyl aldehydes were subsequently shown to be versatile precursors for the construction of a variety of enantioenriched trifluoromethylated building blocks.
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The record
- Venue
- Journal of the American Chemical Society
- Topic
- Fluorine in Organic Chemistry
- Field
- Pharmacology, Toxicology and Pharmaceutics
- Canadian institutions
- —
- Funders
- National Institute of General Medical SciencesNatural Sciences and Engineering Research Council of Canada
- Keywords
- TrifluoromethylationChemistryEnantioselective synthesisOrganocatalysisTrifluoromethylOrganic chemistryPhotocatalysisCatalysisHalideCombinatorial chemistry
- Has abstract in OpenAlex
- yes