LPS inhibits ILC2 mediated type 2 immunity in the lung (IRC5P.625)
Bibliographic record
Abstract
Abstract The hygiene hypothesis states that the lack of early childhood exposure to infectious agents, which promotes type 1 immunity, results in increased incidents of allergy and asthma, which are predominantly type 2 immune responses. Recently identified group 2 innate lymphoid cells (ILC2s) are essential for the development of protease allergen induced type 2 lung inflammation. To better understand how type 2 immunity is regulated, we tested the effect of LPS-induced type 1 inflammation on ILC2s and type 2 lung inflammation. Intranasal LPS pretreatment of mice suppressed both papain- and IL-33-induced ILC2 activation and eosinophilic lung inflammation. Specifically, the number of activated ILC2s that express IL-5 and IL-13 was decreased with LPS treatment. The LPS effect on ILC2s was dose and time dependent. The in vivo findings were reproduced in vitro. Pretreatment with LPS inhibited the production of type 2 cytokines IL-5 and IL-13 by ILC2s cultured in the presence of IL-33 and TSLP. These results indicate that LPS triggers an ILC2 inhibitory signal, which leads to the suppression of ILC2 activation and type 2 inflammation in the lung upon allergen exposure.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.002 |
| Insufficient payload (model declined to judge) | 0.000 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".