Abstract 18807: Spatial Distribution of the Metabolically Active Pulmonary Circulation in Humans
Bibliographic record
Abstract
Introduction: Human pulmonary perfusion is not homogeneously distributed. Analysis of pulmonary perfusion spatial distribution (SD) variations, could be useful in the evaluation of pulmonary disorders. We developed a new tracer called PulmoBind (PB), which binds to the adrenomedullin receptor abundantly expressed in the lung endothelium. Nowadays, all imagery methods rely on physical agents distributed within the pulmonary circulation and whose external signals are reflections of perfusion. There is no clinically validated imaging agent that relies on biologic functions of the endothelium properties and could quantitatively assess the spatial distribution of metabolic active pulmonary circulation (SDMAPC). The aim of this study was to determine the ability of the endothelial cell tracer PB to measure the SDMAPC in human. Methods: Healthy subjects (n=20) were included in the PB phase I trial (NCT01539889). SPECT imaging was performed in the supine position 90 min after injection. SD was determined as mean ...
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".