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A pulse‐based diet and exercise training in women with polycystic ovarian syndrome: effects on body composition, blood lipids and reproductive measures (117.5)

2014· article· en· W1480749119 on OpenAlexafffundabout
Laura E. McBreairty, Gordon A. Zello, Julianne Rooke, Shani Serrao, Roger A. Pierson, Donna R. Chizen, Philip D. Chilibeck

Bibliographic record

VenueThe FASEB Journal · 2014
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNutrition, Genetics, and Disease
Canadian institutionsUniversity of Saskatchewan
FundersSaskatchewan Pulse Growers
KeywordsPolycystic ovaryMedicineInternal medicineEndocrinologyLean body massBody mass indexInfertilityObesityAntral follicleMenstrual cyclePhysiologyOvaryPregnancyBiologyInsulin resistanceHormoneBody weight

Abstract

fetched live from OpenAlex

Polycystic ovarian syndrome (PCOS) is an endocrine disorder that predisposes women to an increased risk of heart disease, diabetes, infertility and endometrial cancer with an annual cost of $4 billion in the United States. We hypothesized that a pulse‐based diet (e.g. beans, lentils) would have a positive effect on body composition as analyzed by dual energy X‐ray absorptiometry, reproductive measures and serum lipid profiles. Twenty‐five women with PCOS aged 18‐35y with a mean BMI of 31 were randomly assigned to groups receiving a pulse‐based diet (n=14) or the National Cholesterol Education Program (NCEP) therapeutic lifestyle changes (TLC) diet (n=11) for 16 wks while participating in an exercise program. Following the intervention, both groups lost body mass (p<0.05; Pulse ‐2.4 vs TLC ‐3.0 kg), percent fat mass (Pulse ‐1.0 vs TLC ‐1.6 %) and trunk fat mass (Pulse ‐1.0 vs TLC ‐1.7 kg). No changes were observed in lean body mass between groups. Both dietary interventions also resulted in more women exhibiting regular menstrual patterns (p<0.001) and a tendency towards a decreased antral follicle count in the right ovary (p=0.06); however, only the pulse diet reduced total cholesterol to HDL ratio (4.2 to 3.8 p<0.005). As hypothesized, a pulse‐based diet reduced body fat, and improved reproductive measures and serum lipid profiles. Thus, early diagnosis and dietary/exercise interventions are important in alleviating both the personal health and economic costs associated with PCOS. Grant Funding Source : Supported by the Saskatchewan Pulse Growers and Agriculture Agri‐Food Canada (Cluster Program)

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Non-randomized trial · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.008

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.007
GPT teacher head0.211
Teacher spread0.204 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNon-randomized trial
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2014
Admission routes3
Has abstractyes

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