Prevalence of ganglionic AChR antibodies in postural tachycardia syndrome (POTS) (P1.276)
Bibliographic record
Abstract
OBJECTIVE: To determine the prevalence and relevance of ganglionic AChR antibody in patients with POTS BACKGROUND: Postural tachycardia syndrome (POTS) is a common form of autonomic dysfunction characterized by inappropriate and excessive increase in heart rate when standing. The precise pathophysiology of POTS remains unclear, and several different etiologies may produce the same clinical syndrome. Association with various autoimmune disorders has been reported. In retrospective studies from the Mayo Clinic, low levels of ganglionic AChR antibodies were found in 7-14[percnt] of POTS patients. This seropositive rate may be artificially higher (due to retrospective referral bias) than the prevalence of ganglionic AChR antibody in routine clinical autonomic practice. DESIGN/METHODS: Through a patient support and advocacy group (Dysautonomia International), patients with dysautonomia were invited to participate in a study of serological markers for POTS. Patients (and healthy family members) provided clinical information, blood samples, and orthostatic vital signs. Blinded blood samples from 103 POTS patients and 66 healthy controls were tested for ganglionic AChR antibodies using validated radioimmunopreciptation assay. RESULTS: Five POTS patients (4.8[percnt]) and two healthy controls (3[percnt]) were positive for ganglionic AChR antibodies. Three of the subjects (2 POTS and one control) had very low antibody level (0.06 nmol/L; normal < 0.05). Antibody levels (0.08 - 0.11 nmol/L) in the others were lower than those typically seen in autoimmune autonomic ganglionopathy. CONCLUSIONS: In this prospective study of unselected but well-characterized subjects, a small minority of patients with POTS (5[percnt]) were seropositive. Neither prevalence nor antibody level was significantly different from healthy controls. At these low antibody levels, clinical specificity is poor. We will report the clinical characteristics of the five seropositive cases to determine if they represent a definable phenotype.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".