CORM‐3 derived CO suppresses NLRP3 inflammasome in cardiac fibroblasts and protects cardiomyocytes from apoptosis in mice with sepsis (1096.6)
Bibliographic record
Abstract
The study is to examine the role of CO derived from CORM‐3 on NLRP3 inflammasome activation in cardiac fibroblast (CF) and its effect on cardiomyocyte apoptosis and myocardial dysfunction in mice with sepsis. Methods: CFs were primed with LPS and followed by ATP treatment with or without CORM‐3. CF NLRP3 expression and NLRP3 inflammasome activation assessed. Cardiomyocyte apoptosis and myocardial function were measured in mice with LPS. Results : LPS priming and ATP treatment to CFs resulted in NLRP3 inflammasome activation as indicated by increase in cleaved caspase‐1 p20 and matured IL‐1β. CFs with NLRP3 siRNA abolished caspase‐1 cleavage and IL‐1β maturation. CORM‐3 attenuated the increase in NLRP3 and pro‐IL‐1β expression in LPS primed CFs and prevented NLRP3 inflammasome activation. CORM‐3 inhibited NLRP3‐mediated ASC pyroptosome formation. Myocardial NLRP3, pro‐capase‐1, p20, pro‐IL‐1β and IL‐1β were increased, cardiomyocyte apoptosis was induced and myocardial contractility was decreased in mice with LPS. CORM3 prevented the myocardial NLPR3 inflammasome activation, attenuated cardiomyocytes apoptosis, and improved cardiac function in mice with LPS. Conclusions : CORM‐3‐derived CO suppresses NLRP3 inflammasome priming and activation in CFs and protects myocardium from apoptosis and dysfunction in mice with endotoxemia. (HSFO 2012‐000212) Grant Funding Source : Heart and Stroke Foundation of Ontario
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".